By: Neha Sahu
Research Scholar, Lingaya’s Vidyapeeth, Faridabad, Haryana
Multicomponent reactions (MCRs) represent an efficient and versatile approach in organic synthesis, enabling the formation of complex molecules through a single, one-pot procedure. This methodology is particularly advantageous for the synthesis of heterocyclic compounds that are prevalent in numerous biologically active molecules and pharmaceuticals. The one-pot nature of MCRs allows for the simultaneous combination of three or more reactants, leading to high atom economy, reduced reaction times, and minimized purification steps. This abstract explores the principles and applications of one-pot MCRs in the synthesis of various heterocyclic frameworks, highlighting recent advancements and key strategies employed to enhance reaction efficiency and selectivity. Through representative examples, we demonstrate how MCRs can be utilized to construct a diverse array of heterocycles, including pyridines, pyrimidines, imidazoles, and oxazoles, under mild and environmentally benign conditions. The potential of one-pot MCRs to streamline the synthesis of complex heterocyclic architectures positions them as a powerful tool in modern synthetic organic chemistry.
Citation:
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