Biosensors Powered by Nanotechnology forContinuous Insulin Delivery and GlucoseMonitoring in Diabetes Management

Volume: 10 | Issue: 01 | Year 2024 | Subscription
International Journal of Applied Nanotechnology
Received Date: 05/26/2024
Acceptance Date: 06/06/2024
Published On: 2024-07-02
First Page: 13
Last Page: 24

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By: Seethaladevi .


Diabetes mellitus is a chronic metabolic disorder that necessitates continuous glucose monitoring and precise insulin delivery for effective management. Traditional methods often fall short in maintaining the necessary levels of accuracy and convenience, thereby posing challenges in achieving optimal glycemic control. Nanotechnology-enabled biosensors have revolutionized this field by leveraging the unique properties of nanomaterials, offering significant improvements in sensitivity, selectivity, and biocompatibility. This article delves deeply into the transformative role of nanotechnology in developing advanced biosensors specifically designed for continuous glucose monitoring and insulin delivery. The discussion begins with an exploration of enzymatic and non-enzymatic glucose biosensors. Enzymatic glucose biosensors typically employ glucose oxidase or glucose dehydrogenase, which facilitate the oxidation of glucose, producing measurable signals that are directly proportional to glucose concentrations. In contrast, non-enzymatic glucose biosensors capitalize on the properties of nanomaterials such as metal nanoparticles, carbon nanotubes, and graphene. These materials interact directly with glucose molecules, offering advantages such as enhanced stability and a longer shelf-life. Additionally, the article investigates nanostructured platforms designed for insulin monitoring and controlled delivery. These platforms include nanocarriers like liposomes, polymeric nanoparticles, and dendrimers, which protect insulin from degradation and enable targeted, sustained release. Some of these nanocarriers are engineered to respond to specific physiological stimuli, such as pH or glucose levels, allowing for on-demand insulin release that maintains optimal blood glucose levels. The integration of these advanced biosensors with closed-loop systems and artificial intelligence (AI) is another focal point. Closed-loop systems, also known as artificial pancreas systems, automate the monitoring of glucose levels and the delivery of insulin, thereby closely mimicking the body’s natural regulatory mechanisms. AI algorithms further enhance these systems by analyzing continuous data streams, predicting glucose trends, and adjusting insulin doses in real-time.

Keywords: Nanotechnology, biosensors, continuous glucose monitoring, insulin delivery, diabetes
management, closed-loop systems, Artificial Intelligence



How to cite this article: Seethaladevi ., Biosensors Powered by Nanotechnology forContinuous Insulin Delivery and GlucoseMonitoring in Diabetes Management. International Journal of Applied Nanotechnology. 2024; 10(01): 13-24p.

How to cite this URL: Seethaladevi ., Biosensors Powered by Nanotechnology forContinuous Insulin Delivery and GlucoseMonitoring in Diabetes Management. International Journal of Applied Nanotechnology. 2024; 10(01): 13-24p. Available from:


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