Employing ML and DL to Optimize an ElectrochemicalBiosensor

Volume: 10 | Issue: 01 | Year 2024 | Subscription
International Journal of Chemical Separation Technology
Received Date: 05/08/2024
Acceptance Date: 06/23/2024
Published On: 2024-07-30
First Page: 33
Last Page: 38

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By: Yashas A Mithra, Yashaswini D.M., Salma Itagi, and M.S. Ganesha Prasad

1Student, Department of Computer Science & Engineering, Sai Vidya Institute of Technology, Bengaluru, Karnataka, India
2-3Professor, Department of Computer Science & Engineering, Sai Vidya Institute of Technology, Bengaluru, Karnataka, India
4Principal, Sai Vidya Institute of Technology, Bengaluru, Karnataka, India

Abstract

A major field of study in science, that have made the understanding of the world and made homo sapiens
the dominant species on the planet is our understanding of medicine. Under this vast umbrella is the
detection and classification of microorganisms. Electrochemical biosensors have emerged as
promising tools in this regard due to their high sensitivity, selectivity, and potential for miniaturization.
By integrating a Machine Learning & Deep Learning model for the detection of the bacterium in the
sample and also to see how different physical and chemical environmental characteristics affect the
working of the sensor. The working of the project is quite elementary, as a sensor is simulated on
COMSOL Multiphysics, in a particular environment, with varying factors of Sensor factors, namely:
Electrode Shape, Material & height, material of the substrate and the dielectric used. This is done to test
varying factors and to find the best combination of materials that produce the most consistent and
accurate values. Following which, the data generated from the simulation, which will be a set of electric
field values can be processed and mutated to the required format and will be fed into the machine
learning algorithm to be trained. The algorithm best suited is the Random Forest Method, where a
decision tree is formed to detect the bacteria present in the sample. Further, a Deep Learning model
can also be trained to add a layer of complexity, which shows how each of the underlying chemical &
physical properties of different bacterium play a role in generating the final peak electric field values.
This works as the chemical & physical properties is unique to every bacterium. If implemented and
developed, this project can act as a lifesaver in disease detection as “Prevention is better than cure”.
This can correctly can help communities, especially low- income and underprivileged ones. The
applications include, but are not limited to Medical Diagnostics, Environmental Monitoring, Food
Safety, Agriculture, Biotechnology & Pharmaceuticals and Security and Defense.

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Citation:

How to cite this article: Yashas A Mithra, Yashaswini D.M., Salma Itagi, and M.S. Ganesha Prasad, Employing ML and DL to Optimize an ElectrochemicalBiosensor. International Journal of Chemical Separation Technology. 2024; 10(01): 33-38p.

How to cite this URL: Yashas A Mithra, Yashaswini D.M., Salma Itagi, and M.S. Ganesha Prasad, Employing ML and DL to Optimize an ElectrochemicalBiosensor. International Journal of Chemical Separation Technology. 2024; 10(01): 33-38p. Available from:https://journalspub.com/publication/employing-ml-and-dl-to-optimize-an-electrochemicalbiosensor/

Refrences:

1. Pfeffer, C.; Liang, Y.; Grothe, H.; Brederlow, R. “Towards Easy-to-Use Bacteria Sensing: Modeling and Simulation of a New Environmental Impedimetric Biosensor in Fluids”. Sensors 2021, 21, 1487. https://doi.org/10.3390/s21041487
2. S. J. Bharathi, S. H. Thilagar and V. Jayasurya, “Design and Modeling of Electrochemical Sensor for Determining ION Concentration”, 2019 IEEE 1st International Conference on Energy, Systems and Information Processing (ICESIP), Chennai, India, 2019, pp. 1-5, doi:
10.1109/ICESIP46348.2019.8938357.
3. Jasmina Vidic, Marisa Manzano, “Electrochemical biosensors for rapid pathogen detection, Current Opinion in Electrochemistry”, Volume 29,2021,100750,  ISSN 2451- 9103, https://doi.org/10.1016/j.coelec.2021.100750.
4. Banakar, M.; Hamidi, M.; Khurshid, Z.; Zafar, M.S.; Sapkota, J.; Azizian, R.; Rokaya, D.= “Electrochemical Biosensors for Pathogen Detection: An Updated Review”. Biosensors 2022, 12, 927. https://doi.org/10.3390/bios12110927
5. Ofer Prinz Setter, Xin Jiang, Ester Segal, “Rising to the surface: capturing and detecting bacteria by rationally-designed surfaces”, Current Opinion in Biotechnology, Volume 83, 2023, 102969, ISSN 0958-1669, https://doi.org/10.1016/j.copbio.2023.102969.
6. “Machine learning and chemometrics for electrochemical sensors: moving forward to the future of analytical chemistry” by Pumidech Puthongkham, Supacha Wirojsaengthonga and Akkapol Suea Ngam on 7 Sept 2021. DOI: https://doi.org/10.1039/D1AN01148K
7. “Machine Learning for Biosensors” by Gayathri Anapanani in 2023, for Statler College of Engineering and
Mineral Resources at
West Virginia University. DOI: https://doi.org/10.33915/etd.12118
8. “Machine learning toward high‐performance electrochemical sensors” by Gabriela F. Giordano, Larissa F. Ferreira, Ítalo R. S. Bezerra, Júlia A. Barbosa, Juliana N. Y. Costa, Gabriel J. C. Pimentel & Renato S. Lima. DOI: 10.1007/s00216-023-04514-z
9. “Advancing Biosensors with Machine Learning” by Feiyun Cui, Yun Yue, Yi Zhang, Ziming Zhang, and H. Susan Zhou on November 13, 2020 in 2020 American Chemical Society. https://doi.org/10.1021/acssensors.0c01424
10. Sahar Sadat Mahshid, Sarah Elizabeth Flynn, Sara Mahshid, “The potential application of electrochemical biosensors in the COVID-19 pandemic: A perspective on the rapid dianostics of SARS-CoV-2, Biosensors and Bioelectronics”, Volume 176, 2021, 112905, ISSN 0956-5663, https://doi.org/10.1016/j.bios.2020.112905 Sensor
11. Nam Ha, Kai Xu, Guanghui Ren, Arnan Mitchell, and Jian Zhen Ou, “Machine Learning- Enabled Smart
Systems” in Advanced Intelligent Systems, 14 July 2020 https://doi.org/10.1002/aisy.202000063