By: Neha Sahu
School of Basic and Applied Sciences, Lingaya’s Vidyapeeth, Faridabad, Haryana
The study focuses on the synthesis, characterization, and analysis of heterocyclic oxadiazole derivatives using various spectroscopic techniques, including UV-visible (UV-Vis) spectroscopy and infrared (IR) spectroscopy. Oxadiazoles are a type of five-membered heterocyclic compounds with nitrogen and oxygen atoms. They are important in medical chemistry and materials research and show a wide range of biological activity. The synthesized oxadiazole derivatives were characterized through UV-Vis spectroscopy to investigate their electronic transitions and absorption maxima. The UV-Vis spectra provided insights into the electronic structure and conjugation of the derivatives, which are crucial for understanding their potential applications in optoelectronic devices. Infrared spectroscopy was employed to elucidate the functional groups and molecular vibrations present in the oxadiazole derivatives. The IR spectra revealed characteristic absorption bands corresponding to the oxadiazole ring and other substituents, allowing for the identification and confirmation of the molecular structure of the synthesized compounds. Synthesis and Characterization: The oxadiazole derivatives were synthesized through established synthetic routes involving the cyclization of appropriate hydrazides with carboxylic acids or their derivatives. Mass spectrometry and elemental analysis were used to verify the synthesized compounds’ structural integrity and purity. This study contributes to the development of new oxadiazole-based materials with potential applications in various fields, including pharmaceuticals, agrochemicals, and advanced materials. The comprehensive spectroscopic analysis of heterocyclic oxadiazole derivatives using UV-Vis, IR, and NMR spectroscopy provides a deep understanding of their structural and electronic properties. These techniques collectively confirm the successful synthesis and purity of the compounds, highlighting their potential for further application in various scientific and industrial fields.
Citation:
Refrences:
1.Ahsan MJ, Hassan MZ, Jadav SS, Geesi MH (2020) Synthesis and Biological Potentials of 5-aryl-N-[4-(trifluoromethyl) phenyl]-1,3,4-oxadiazol-2-amines. Lett Org Chem 17:133–140
2.Mamatha SV, Mahesh B, Kumara HK, Gowda DC, Meenakshi SK (2020) Design, synthesis and SAR evaluation of mercaptooxadiazole analogs as anti-tubercular, anti-diabetic and anti-bacterial agents. Chem Data Collect 20:100343
3.Mamatha SV, Belagali SL, Mahesh B (2019) Design, synthesis and SAR bioevaluation of benzophenone-mercaptooxadiazole analogs. Med Drug Dis 3:100017
4.Mamatha SV, Bhat M, Sagar BK, Meenakshi SK (2019) Synthesis, characterization, crystal structure biological activity of 4-{2-[5-(4-fluoro-phenyl)-[1, 3, 4] oxadiazol-2-ylsulfanyl]-ethyl}-morpholine. J Mol Struct 1196:186–193
5.Mamatha SV, Belagali SL, Bhat M (2019) Synthesis and SAR evaluation of mercapto triazolobenzothiazole derivatives as anti-tuberculosis agents. Anti-Infect Agents 18:1–13
6.Carbothioamide Based Pyrazoline Derivative: Synthesis, Single Crystal Structure, DFT/TD-DFT, Hirshfeld Surface Analysis and Biological Studies Manish Rana et al. Polycyclic Aromatic Compounds Published online: 29 Aug 2022
7.Novel dihydrobenzofuran derivatives: design, synthesis, cytotoxic activity, apoptosis, molecular modelling and DNA binding studies Manish Rana et al.Journal of Biomolecular Structure and Dynamics Published online: 30 Oct 2023
8.Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review Jing-Jing Wang et al. Journal of Enzyme Inhibition and Medicinal Chemistry Published online: 23 Aug 2022
9.Synthesis, spectral characterization of pyrazole derived Schiff base analogs: molecular dynamic simulation, antibacterial and DNA binding studies Razia Sultana et al. Journal of Biomolecular Structure and Dynamics Published online: 24 Feb 2023
10.4-Bromo-1,8-Naphthalimide derivatives as Antifungal Agents: Synthesis, Characterization, DNA Binding, Molecular docking, Antioxidant and ADMET studies Nouman et al. Polycyclic Aromatic Compounds Published online: 6 Mar 2023
11.An Overview of the Synthetic Routes and Pharmacological Aspects of Pyridine, Isoxazole, Thiazole, and Indole Derivatives Pallavi H.M. et al. Polycyclic Aromatic Compounds Published online: 22 Dec 2023
12.”Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazole derivatives,” by A. A. Isloor et al., European Journal of Medicinal Chemistry, 2011, which discusses the UV-Vis spectral properties of synthesized oxadiazole derivatives.
13.”Synthesis and characterization of 1,3,4-oxadiazole derivatives: A spectral and thermal study,” by N. K. Ghera et al., Journal of Molecular Structure, 2007, which provides detailed IR spectral analysis of various oxadiazole derivatives.
14.Fragmentation pathways of oxadiazole derivatives studied by mass spectrometry,” by J. M. Aizpurua et al., Journal of Mass Spectrometry, 2002, which explores the MS fragmentation patterns of different oxadiazole derivatives.
15.A convenient Synthesis of 3-aryl-5-Hydroxyalkyl-1,2,4-oxadiazoles from a-hydroxy Esters and Amidoximes under Solvent-free Conditions Article Dec 2021
16.Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions Article Sep 2021
17.Mickevičius V, Vaickelioniene R, Sapijanskaite B. Synthesis of substituted 1,3,4-oxadiazole derivatives. Chemistry of Heterocyclic Compounds. 2009;45(2):215–218.
