By: Prof. Gizachew Diga Milki
Associate Professor, Department of Physics, Jimma University, Ethiopia.
In this paper, the essence of nanotechnology is presented. Nanotechnology is emerged as a fabrication method, computational tools, and revolutionized electronics and medicine. The bio-chemo-physical properties are understood in different dimension with emphasis on various synthesis techniques and size dependent physio-chemical properties. Most properties resulting from size reduction from macro scale to nanoscale and molecular interactions with nanoparticles significantly contributes to its multi function. A systematic illustration of nanotechnology at nanoparticles level indicate a plenty of nanotechnology applications. More specifically, the role of nanostructures such as nanoparticles, quantum dots, and DNA nanostructures as a carrier of fluorescence and molecular medicine is digested. Here in, the essence of nanotechnology is visualized by accounting the potential of nanoparticles in molecular electronics and molecular medicine. The consensus of nanotechnology and its significant role in molecular electronics, molecular medicine, and nano medicine is presented. In the perspective or molecular electronics, the significant role of nanotechnology is demstfied for Bioelectronics and biochip processing. However, molecular imaging, identification of molecular mismatch, genetic errors, immunotherapy, and diagnosis are seen as a significant attribute of nanotechnology in molecular medicine. The current challenges and life fate resulting from nano products such as nano waste, nano toxicity, and dust nanoparticles are also visualized.
Key words: molecular medicine, nano medicine, nanotechnology, nanoparticles, nanocomposite.
Citation:
Refrences:
- Loutfy H. Madkour. Introduction to nanotechnology (NT) and nanomaterials, (2019) V. 116
- S. Khan et al. Effects of nanotechnology on global warming. Preceding of Midwest section conference American society for engineering education.2012.
- A et al. Bionanomaterials: Understanding key biophysics, and their applications, nanotechnology, 2013, Vol. 11. Pp. 42-110.
- J. Paukstelis & N. C. Seeman. 3D DNA Crystals and Nanotechnology, Crystals 2016, 6, 97
- Kumar et al. DNA Nanotechnology for Cancer Therapy. Theranostics. 2016, Vol. 6, Issue 5. Pp. 710-725. doi: 10.7150/thno.14203
- Watson, Davide Marenduzzo, Crick, and Franklin. The Physics of DNA and chromosomes. 2021. 1 Pp. 1-35
- Dan Huang et al. Information processing using an integrated DNA reaction network, 2021, 13, and 5706 -5713.
- James Allen. Chemical bonding and protein structures, 2008, ISBN: 978-1-4051-2436-2
- Damodaran Vasudevan et al. Protein structure and function, textbook of Biochemistry for Medical Students. 2019. 13014 – 5, Pp.36-51.
- Atkins and Julio de Paula. Elements of Physical chemistry, 2009, 5thedt. 373-387
- Lucia Herrer, Santiago Martin and Pilar Cea, nanofabrication Techniques in large area molecular Electronic Devices, Appl. Sci. 2020, 10, 6064
- Shuang Wang et al. DNA-Grafted 3D Super lattice Self-Assembly, Int. J. Mol. Sci. 2021, 22. 7558.
- A G Pershina, A E Sazonov, V D Filimonov Russ. Magnetic nanoparticles DNA interactions: design and applications of nanobiohybrid systems Chem. Rev. 2014. 83 (4) 299 – 322
- C. Seeman and F. Sleiman. Structural DNA nanotechnology, Nano Lett. 2010, 10, 6, 1971–1978
- Bake well D. J, Vergara Irigaray N, Holmes D. Dielectrophoresis of Biomolecules. JSM Nanotechnol Nanomed. 2013. 1 (1): 1003
- Jia-Ying Din et al.Nano drug delivery systems: a promising approach to scar prevention and treatment. J. Nanobiotechnology. 2023; 21: 268.
- Sharma et al. Green synthesis of multipurpose carbon quantum dots from red cabbage and estimation of their antioxidant potential and bio-labeling activity, J appl. Microbiology and Biotechnology, (2020) 104
- Malavika et al. Green synthesis of multifunctional carbon quantum dots: An approach in cancer theranostics, 2021 V. 136, 212756
- Byrappaa and T. Adschiri. Hydrothermal technology for nanotechnology. Progress in Crystal Growth and Characterization of Material. 2007. 53. 117e166
- Ajay Vasudeo Ran et al. Methods for Synthesis of Nanoparticles and Fabrication of Nanocomposite. Elsevier Ltd. pp. 121-139.
- Rui Jiang et al. Ultrafast Synthesis for Functional Nanomaterials, 2021, V. 2, 1, 100302.
- Li et al. Classification, Synthesis, and Application of Luminescent Silica Nanoparticles: a Review. 2019, 14:190.
- Park and J. W. Park.Preparation, characterization, and stability of lipid nanoparticles including unsaturated lipids. Tenside Surfact. Det. 2023; 60 (6): 594–598
- Shreya Geol et al. Positron Emission Tomography and Nanotechnology: A Dynamic Duo for Cancer Theranostics. Adv. Drug delivery rev. 2017 Apr; 113: 157-176.
- Hai Quan Mao et al. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. Journal of controlled release. 2001, V.70 Issue 3, Pp. 399-421.
- M Lindsay (2010). Introduction to nanoscience and technology. Oxford University press. Pp.263-316.
- Arab Hasani et al. Smart materials for health care from sensor and actuators to self sustained nano energy and nano systems. Smart materials in Medicine. 2020. V.1 pp. 92-124.
- William McCurdy et al. Theory and Modeling in Nanoscience, 2002, CA 94720, pp. 1- 46.
- Rasoul Bayaniahangar et al. Sensors and actuators B. Chemical 2024, V. 326. 1 January 2021, 128781.
- Haitao Lin et al. preparation of Carbon Dots with High-Fluorescence Quantum
Yield and their application in dopamine fluorescence probe and cellular Imaging, 2019, V. 9, № 5037243 - Mukhopardhyay S. et al. Solid state proteins Junctions, Cross laboratory study shows preservation of Mechanisms at varying electronic coupling, I. Science, 2020. 23(5). 101099.
- Sara Soares et al. Nanomedicine: Principles, Properties, and Regulatory Issues. Front. Chem. V. 6. 20
- John F.Mongillo (2007). Nanotechnology 101. Green wood press. Issue. 1931-3950, pp.275.
- Coe et al. Magnetism and Magnetic Materials. Cambridge Univ. Press. 2010. pp. 542-578
- Y. Zhao. Nanotechnology in China. Adv. Healthcare Mater. 2018, 7, 1801051
- Jeremy Ramsden. Nanotechnology; an introduction, 2011 Pp 52-72.
- Yalcin and U. Gündüz. Iron Oxide-Based Polymeric Magnetic Nanoparticles for Drug and Gene Delivery, 2019.
- K. Ghoshal, M. R. Sahar, M. S. Rohani and Sunita Sharma, Nanophotonics for 21st Century, (2011), ISBN: 978-953-307-576-1
- Soeller et al. DNA-sensors based on functionalized conducting polymers and quantum dots, conference. 2006, V. 6416-01
- Peter J.F Harris. Carbon nanotube and related structure. Materials Science, Physics. 119779113.
- Paul J. Paukstelis et al. 3D DNA Crystals and Nanotechnology. Crystals. 2016, 6, 97
- T. Islam, and M.A Uddin. Biosensors, the Emerging Tools in the identification and detection of cancer markers. 2017. V. 5, No 4
- W. Lin and C. C. Chang, breast cancer detection using surface Plasmon resonance based Biosensors. Biosensors and Cancer. 2012. Pp. 229-246.
- Michael J. Mitcholl et al. Engineering precision nanoparticles for drug delivery. Review. 2021. V.20. PP. 101-124.
- A. Meador et al. Draft nanotechnology road map Technology area. 2010, 2-10.
- Rotem B. Hamo et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers (2020) 11: 329
- Fatima Akram, Zeeshan Ahmed, Ikram Ul Haq, Hamza Khan, CRISPR-Cas9, a promising theraputic tool for cancer therapy; proteins & Peptides letters. 2020. 27, pp. 1-14.
- Vijayalakshmi et al. Nanotechnology in Periodontics. Medico-legal Update, 2020, Vol. 20, No. 4.
- Lingling Ou et al., Toxicity of Graphene-family nanoparticles: a general review of the origins and mechanisms, Particle and Fiber Toxicology (2016) 13:57
- Siddique and J. C. L. Chow. Application of Nanomaterials in Biomedical Imaging and Cancer Therapy, Nanomaterials 2020. 10. 1700; doi:10.3390/nano10091700
- Vasif Hasirici, Nesrin Hasirici. Fundamentals of bionanomaterials. Elsevier. (2018), 1st ISBN 9780128241479.
52. Yaping Liu et al. Toxicity of manufactured nanomaterials. Particuology. 2022. V. PP. 31-48.