By: Hussniya al Difar
Associated Professor of Organic Chemistry, Chemistry Department, Science Faculty, University of Benghazi, Libya.
| In a successful trial to synthesize pyrazole derivatives, acetophenone was, first, reacted with phenylhydrazine producing the Schiffs’s base condensation product (E)-1-phenyl-2-(2-phenylethylidene) hydrazine 1. The application of Vilsmeier Haack’s reaction on this product afforded the cyclization product (1,3-diphenyl-1H-pyrazole-4-carbaldehyde 2 as a pyrazole derivative in good yield percentage. The treatment of (1,3-diphenyl-1H-pyrazole-4-carbaldehyde (2) with acetophenone results in the formation of another pyrazole derivative (3), having a chalcone moiety.The chemical structure of newly formed pyrazole derivatives was confirmed based on spectral data, and these compounds were screened for their anti-bacterial activity. Further exploration of the synthetic potential of compound (2) involved its reaction with acetophenone, resulting in the formation of another pyrazole derivative (3) incorporating a chalcone moiety. This newly formed compound exhibited a distinct structural characteristic, distinguished by the presence of a chalcone unit. Comprehensive spectral analysis was employed to elucidate the chemical structures of these newly synthesized pyrazole derivatives. Furthermore, these compounds were evaluated for their potential antibacterial activities. The results obtained from this screening process shed light on the antibacterial efficacy of these pyrazole derivatives, offering valuable insights into their potential applications in the field of medicinal chemistry. To assess their potential applications, these pyrazole derivatives were evaluated for their antibacterial activities. The screening results provided valuable insights into their efficacy against various bacterial strains, highlighting their potential as promising candidates for further investigation in the field of medicinal chemistry. |
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