A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines

Volume: 10 | Issue: 01 | Year 2024 | Subscription
International Journal of Composite and Constituent Materials
Received Date: 07/26/2024
Acceptance Date: 08/25/2024
Published On: 2024-10-03
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By: Jecinta Wanjiru Ndungu

Research Scientist, Department of Centre for Traditional Medicine and Drug Research (CTMDR), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

Abstract

Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an innovative drug delivery means to overcome these medical challenges. Drug delivery strategies do utilize these elegant bioactive compounds because they are able to cross via systems barriers and deliver the compound to the cells or tissues. Lipid loaded nanoparticles, being a promising drug delivery system can protect therapeutics, such as hydrophobic, hydrophilic and amphiphilic compounds from unfavorable conditions such as pH and enzyme degradation and oxidation. The lipids in advance form influence the fate and the transport of drug in gastrointestinal tract through various mechanisms such as enhanced dissolution kinetics, triggers drug precipitation and enhance drug permeation when the lipid emulsion deplete. They also enhance pharmacokinetics such as increased stability, lengthening half-life, clearance and reduced side effects. They ensure sufficient solubility of drugs that have higher systemic toxicity, drug resistance possibility and poor targeting when used as free drugs thus improved bioavailability. This review aims to explore different lipid delivery systems of medicinal plant extracts, essential oils and bioactive compounds that deliver bioactive compounds from medicinal plants on breast cancer cell lines that aid in improving their bioavailability and thus improved efficacy.

Keywords: Therapeutic agents, target sites, solubility, bioavailability, solid lipid nanoparticles, drug delivery system

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How to cite this article: Jecinta Wanjiru Ndungu, A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines. International Journal of Composite and Constituent Materials. 2024; 10(01): -p.

How to cite this URL: Jecinta Wanjiru Ndungu, A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines. International Journal of Composite and Constituent Materials. 2024; 10(01): -p. Available from:https://journalspub.com/publication/ijccm-v10i01-10906/
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