Background: Central venous catheters (CVCs) are frequently utilized in healthcare environments, especially within intensive care units (ICUs), for various medical purposes. They are inserted to facilitate the delivery of fluids, blood products, medications, parenteral nutrition, as well as for monitoring central venous pressure and performing dialysis. Objectives: The main objective of the study was to assess the effectiveness of heparin saline compared to 0.9% sodium chloride in ensuring the patency of central venous catheters in the PCCM department at PGIMS, Rohtak. Methods: A randomized controlled trial included 100 patients with central venous catheters, selected using a sequentially numbered, snose sampling method. The study assessed the impact of heparin saline and 0.9% sodium chloride solution on maintaining catheter patency using a checklist, with evaluations conducted on days 1, 3, and 5. Variables under study dependent variables such as patency of central venous catheter and independent variables such as Heparin saline and normal saline Results: Overall, Heparin Saline appears to be more effective in maintaining the patency of the central venous catheter compared to 0.9% Sodium Chloride particularly on Day 3 and Day 5. Heparin Saline shows higher mean scores and lower variability (smaller standard deviations) across all three days compared to 0.9% Sodium Chloride. The t-tests confirm that the difference in means between Heparin Saline and 0.9% Sodium Chloride is statistically significant on Day 3 and Day 5 suggesting a consistent advantage of Heparin Saline in maintaining catheter patency on these days. Conclusion: The study was conducted on patient with central venous catheter. The study sample was 100.The sample was divided in to group 1 heparin saline and group 2 normal saline each containing 50 subjects. Heparin saline flush was applied on the subjects of group 1 two times a day on day1, day3 and day5 whereas normal saline flush was applied on subjects of group 2 two times a day on day1, day3 and day5.The result of the finding showed that both the interventions were helpful in maintaining patency of central venous catheter but the heparin saline was more effective.

KEYWORDS: Heparin Saline, 0.9% Sodium Chloride, Substitution, Physical health care needs, Mental health care needs.

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