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By: M. L. Indhumathi, B. Premkumar, M. Mumtaj Begum, S. Srimathi, P. P, Rashida Fahmi, T. Sathyamoorty, and M. P. Jassim.
1 Assistant Professor, Department of Pharmaceutics & Biotechnology, Sree
Abirami College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu,
India. [Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
2 Professor & HOD, Department of Pharmaceutics & Biotechnology, Sree
Abirami College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu,
India. [Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
3 Assistant Professor, Department of Pharmaceutics & Biotechnology, Sree
Abirami College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu,
India. [Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
4 Students, Department of Pharmaceutics & Biotechnology, Sree Abirami
College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu, India.
[Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
5 Students, Department of Pharmaceutics & Biotechnology, Sree Abirami
College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu, India.
[Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
6 Students, Department of Pharmaceutics & Biotechnology, Sree Abirami
College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu, India.
[Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
7 Students, Department of Pharmaceutics & Biotechnology, Sree Abirami
College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu, India.
[Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
8 Students, Department of Pharmaceutics & Biotechnology, Sree Abirami
College of Pharmacy, Eachanari, Coimbatore – 641 021, Tamil Nadu, India.
[Affiliated to The Tamil Nadu Dr. M. G. R. Medical University, Chennai
This research focused on evaluating the potential anti-cervical cancer properties of silver nanoparticles (AgNPs) that were synthesized using an aqueous extract derived from the rhizome of Zingiber officinale (ginger). The synthesized silver nanoparticles (AgNPs) were thoroughly characterized using a range of analytical techniques, including Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Field Emission Scanning Electron Microscopy (FESEM).Characterization studies revealed that the synthesized silver nanoparticles (AgNPs) exhibited an average size range of 85–104 nm, with predominantly round and linear morphologies, dispersed in a small, scattered arrangement. Furthermore, the presence of antioxidant compounds was found using DPPH (2,2 -diphenyl -1- picrylhydrazyl) and total antioxidant test. The DPPH result was found to be 74.89% and total antioxidant test gives 38.2mg/g which provides the substantial anticancer activity of plant extract. The cytotoxic potential of the synthesized AgNPs was evaluated against cervical cancer (HeLa) cell line using MTT assay [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay] shows more apoptosis at high concentration. The biosynthesized AgNPs demonstrated cytotoxic effects in HeLa cells, indicating the anticancer potential of ZO- AgNPs. These findings suggest their possible application in the treatment of cervical cancer.
Keywords: Silver nanoparticles, Zingiber officinale, biosynthesis, cervical, cancer, apoptosis.
Citation:
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