Abstract: Polyethylene (PE), a commonly used synthetic polymer, is highly resistant to natural breakdown, leading to serious environmental and ecological issues such as soil and marine pollution, the formation of microplastics, and risks to wildlife and human health. Recent efforts have focused on using microbial and enzymatic processes to handle polyethylene waste. Microorganisms such as bacteria (Pseudomonas, Bacillus), fungi (Aspergillus, Penicillium), and algae produce enzymes like laccases, peroxidases, oxygenases, and alkane hydroxylases, which help break down polymer chains into smaller molecules such as oligomers and monomers. Progress in omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, has helped scientists understand the molecular processes involved in degradation, which in turn supports the development of engineered microbial communities and enzyme systems. These biotechnological methods are applied in areas such as bioremediation, bioaugmentation in composting, circular bioeconomy strategies, and the production of valuable products like biofuels and bioplastics. Future approaches aim to combine synthetic biology, metabolic engineering, artificial intelligence, and bioinformatics to improve microbial degradation efficiency, discover new enzymes, and advance sustainable waste management practices, contributing to global environmental protection and the development of biodegradable alternatives.
Keywords: Polyethylene, Microbial Degradation, Enzymatic Breakdown, Bioremediation, Synthetic Biology
1.Kumari K, Aanad RC, Narula N. Microbial degradation of polyethylene (PE). The South Pacific Journal of Natural and Applied Sciences. 2009 Dec 15;27(1):66–70. Available from:
https://www.researchgate.net/publication/245492756_Microbial degradation_of_polyethylene_PE 2. Gewert B, Plassmann MM, MacLeod M. Pathways for degradation of plastic polymers floating in the marine environment. Environmental science: processes & impacts. 2015 Sep 1;17(9):1513-21. 3. Al-Salem, S.M., Antelava, A., Constantinou, A.,Manos, G. and Dutta, A. (2017) A Review on Thermal and Catalytic Pyrolysis of Plastic Solid Waste (PSW). Journal of Environmental Management, 197, 177-198. -References - Scientific Research Publishing. Scirp.org. Available from: https://www.scirp.org/reference/referencespapers?referenceid=3767620 . 4. Ghatge S, Yang Y, Ahn JH, Hur HG. Biodegradation of polyethylene: a brief review. Applied Biological Chemistry. 2020 May 16;63(1). Available from:
https://www.researchgate.net/publication/341433719_Bio degradation_of_polyethylene_a_brief_review 5. Wang J, Tan Z, Peng J, Qiu Q, Li M. The behaviors of microplastics in the marine environment. Marine Environmental Research. 2016 Feb;113:7–17. Available from:https://www.researchgate.net/publication/283723944The_behaviors_of_microplastics_in_the_marine_environment 6. Mohanan N, Montazer Z, Sharma PK, Levin DB. Microbial and enzymatic degradation of synthetic plastics. Frontiers in microbiology. 2020 Nov 26;11:580709. 7. Sokra I. Microbial Degradation of Biodegradable Plastics: Enzymes, Pathways, and Applications. ResearchGate . 2026 Oct 25;2(2):12–22. Available from:
https://www.researchgate.net/publication/399345650_Microbial_Degradation_of_Biodegradable_Plastics_Enzymes Pathways_and_Applications 8. Dhali SL, Parida D, Kumar B, Bala K. Recent trends in microbial and enzymatic plastic degradation: a solution for plastic pollution predicaments. Biotechnology for Sustainable Materials. 2024 Aug 12;1(1):11. 9. lee. Tournier Et Al 2023 Enzymes Power for Plastics Degradation. Scribd. 2023. Available from:https://www.scribd.com/document/776161876/Tournier-Et-Al-2023-Enzymes-Power-for-Plastics-Degradation 10. Henawy AR, Ismail SM, Gharib S, Elarabi NI, Abdelhadi AA, Halema AA. Harnessing bacterial power and omics technologies for sustainable plastic waste biodegradation. Biodegradation. 2026 Apr;37(2):46. 11. Purohit J, Chattopadhyay A, Teli B. Metagenomic exploration of plastic degrading microbes for biotechnological application. Current Genomics. 2020 May 1;21(4):253-70. 12. Henawy AR, Ismail SM, Gharib S, Elarabi NI, Abdelhadi AA, Halema AA. Harnessing bacterial power and omics technologies for sustainable plastic waste biodegradation. Biodegradation. 2026 Mar 7;37(2). Available from: https://link.springer.com/article/10.1007/s10532-026-10258-1. Kumari A, Bano N, Bag SK, Chaudhary DR, Jha B. Transcriptome-guided insights into plastic degradation by the marine bacterium. Frontiers in Microbiology. 2021 Sep 27;12:751571. 13. Shehbas MC, Desai DS, Mathew TM, Nampoothiri Microbial enzymes for plastic degradation: a comprehensive review of current status and emerging trends. Biodegradation. 2026 Feb 7;37(2). Available from: https://pubmed.ncbi.nlm.nih.gov/41653333/ . 14. Environment U. Turning off the Tap: How the world can end plastic pollution and create a circular economy. UNEP - UN Environment Programme. 2023. Available from: https://www.unep.org/resources/turning-off-tap-end-plastic-pollution-create-circular-economy 15. Dhali SL, Parida D, Kumar B, Bala K. Recent trends in microbial and enzymatic plastic degradation: a solution for plastic pollution predicaments. Biotechnology for Sustainable Materials. 2024 Aug 12;1(1):11. 16. Zhu B, Wang D, Wei N. Enzyme discovery and engineering for sustainable plastic recycling. Trends in Biotechnology. 2022 Jan;40(1):22–37. Available from: https://www.researchgate.net/publication/349925476_Enzyme_Discovery_and_Engineering_for_Sustainable_Plastic_Recycling 17. Valle-Bravo AV, González CL, González-Soto RA, Serrano LA, García JA, Flores-Huicochea E. Integrating Artificial Intelligence into Circular Strategies for Plastic Recycling and Upcycling. Polymers. 2026 Jan 22;18(2):306. 18. Orlando M, Molla G, Castellani P, Pirillo V, Torretta V, Ferronato N. Microbial enzyme biotechnology to reach plastic waste circularity: current status, problems and perspectives. International Journal of Molecular Sciences. 2023 Feb 15;24(4):3877. 19. Valdivia S, Riquelme C, Carrasco MC, Weisser P, Añazco C, Alarcón A, Alarcón S. Polyethylene microplastics and human cells: a critical review. Toxics. 2025 Sep 5;13(9):756. 20. Mohanan N, Montazer Z, Sharma PK, Levin DB. Microbial and enzymatic degradation of synthetic plastics. Frontiers in microbiology. 2020 Nov 26;11:580709. 21. Liu F, Wang T, Liu XH, Xu N, Pan XL. Efficient biodegradation and upcycling of polyethylene terephthalate mediated by cell-factories. Frontiers in Microbiology. 2025 Jul 2;16:1599470.