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Quantification of Morphine, Codeine, and Dihydrocodeine in Carissa carandas Leaves and Fruit Using LC-MS/MS: The Impact of Drying on Alkaloid ConcentrationBy Meghna Choudhary, Amit Kumar, Ashok Singh
Abstract: This study presents a method for quantifying morphine, codeine, and dihydrocodeine in Carissa carandas (Karonda) leaves and fruit, employing morphine-D3 as an internal standard (1 µg/mL) to ensure accuracy. Samples are prepared at 25 ng/mL and extracted using solvent techniques, with an optional solid-phase extraction step to mitigate matrix effects. Quantification is conducted via LC-MS/MS, providing robust sensitivity. Results show that drying concentrates these alkaloids, particularly morphine in fruit, due …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 1, 2025 · pp. 49–61 Read article →