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Elucidation of Synthetic Mechanism Involved in the Conversion of Zwitterionic Clonixin to Carboxamide Side-ProductBy S. Sudalai Kumar, N. Ramkumar, D. Kodimunthiri
Abstract: N-(3-Chloro-2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide is obtained as a by-product during the synthesis and crystallization of Clonixin (2-(3-chloro-2-methylanilino)nicotinic acid) and its polymorphs, respectively. This conversion was unexpected and it changed the usual investigation path way enabling the formation of neutral and zwitterionic polymorphs in our study on Clonixin in contrary to studies of 2-(p-tolylamino) nicotinic acid investigation. The same conversion is checked in the other synthesized analogs such as 2-(phenylamino)nicotinic acid (PNA), 2-(methyl(phenyl)amino)nicotinic acid …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 2, Issue 1, 2016 Read article →