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Synthesis and Evaluation of Antimicrobial Activity of Some Heterocyclic Moieties of Pyrazole DerivativesBy Hussniya al Difar
Abstract: In a successful trial to synthesize pyrazole derivatives, acetophenone was, first, reacted with phenylhydrazine producing the Schiffs’s base condensation product (E)-1-phenyl-2-(2-phenylethylidene) hydrazine 1. The application of Vilsmeier Haack’s reaction on this product afforded the cyclization product (1,3-diphenyl-1H-pyrazole-4-carbaldehyde 2 as a pyrazole derivative in good yield percentage. The treatment of (1,3-diphenyl-1H-pyrazole-4-carbaldehyde (2) with acetophenone results in the formation of another pyrazole derivative (3), having a chalcone moiety.The chemical structure of newly …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 10, Issue 1, 2025 · pp. 26–36 Read article →