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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat PlasmaBy Poonori Ranjan Kumari, Rudraraju Rameshraju, Ramana Tamminana
Abstract: Abstract A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article →