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Isocoreopsin and Glycogen Phosphorylase – An in-silico Interaction Study: A New Way to Tackle Type 2 Diabetes (T2D)†By Rakshana Manikandan, M. Mala, G. Manikandan, Prakash Vaithyanathan
Abstract: The activity of glycogen phosphorylase (GP) plays a crucial role in regulating glycogen metabolism, and its excessive activity has been closely linked to the pathogenesis of metabolic disorders, such as type 2 diabetes (T2D). Therefore, targeting GP inhibition has emerged as a significant therapeutic strategy for managing this disease. Current research focuses on the discovery and development of novel small molecules capable of suppressing GP activity. Among these, flavonoids have …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 1, 2025 · pp. 76–80 Read article →