High Blood Pressure and Occupational Exposure to Antineoplastic Agents Among Healthcare Professionals

Tigha Bouaziz Nadia

Abstract

Objective: The aim of our study was to determine prevalence and risk for high blood pressure (HBP) among personnel exposed to antineoplastic agents (drugs, ADs) among healthcare workers. Materials and methods: We conducted a descriptive analytical study of 108 exposed to antineoplastic agents in 5 oncology departments and 326 unexposed subjects. All subjects completed a medical and occupational questionnaire. We estimated exposure to ADs using exposure time and the cytotoxic contact index (CCI). We used the following statistical tests: relative risk, odds ratio, logistical regression and multiple correspondence analysis (CMA). Results: Participants’ (N = 426) mean age was 43.2 ± 9.4 years, and most were female (87%). The overall prevalence of HBP was 13.6 %, 14.8% for exposed subjects and 12.5% for unexposed subjects. It was higher among women (15%), nurses (19%) and exposure time with a statistically significant difference (p << 0.01). Exposure to ADs increased the risk of HBP by 1.5. This risk is higher in men (relative risk, RR = 2.63) and nurses (RR = 1.41). Hypertension prevalence increased with the years of exposure (RR = 1.25; seniority ≥ 20 years). After adjusting for confounding factors logistic regression revealed a significant difference between CCI and HBP (p = 0.01). CMA distinguished between categories and observations of hypertension in the two groups showed an association with hypertension and exposure to ADs. Conclusion: The risk of developing hypertension is moderate among healthcare personnel exposed to Ads in oncology department. It is significantly correlated with occupational category, time of exposure and CCI.

High Blood Pressure and Occupational Exposure to Antineoplastic Agents Among Healthcare Professionals

Abstract

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