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International Journal of Chemical Synthesis and Chemical Reactions

Review Paper on Mannich Bases for Heterocyclic Compound Synthesis

  1. S. Ravichandran ✉
  2. Nazmeena Kousar
  3. R. M. Madhumitha Sri

Abstract

Mannich bases are the Lewis bases which are β-amino carbonyl compounds synthesized as the endproducts of well known condensation reaction known as Mannich reaction. These are theaminoalkylation reactions involving the formation of carbon-carbon, carbon-Nitrogen, carbonsulphurbonds. Mannich bases of 2-furylmethylketone, catechol, 4-chlorophenol, derivative ofberberine, lawsone, anisaldehyde, benzaldehyde show diversity of biological activities. Mannichreaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesisof a widespread variety of natural products and pharmaceuticals. Mannich reaction is important forthe construction of nitrogen comprising compounds. There are number of aminoalkyl chain bearing aMannich bases connected to the fluoxetine, atropine, ethacrynic acid and so forth with high curativevalue. Literature studies informed that the Mannich bases are very reactive and predictable to possessthe potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal,analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. Biological activity ofthe Mannich bases are largely accredited to α, β-unsaturated ketone which can be made by thedeamination of hydrogen atom of the amine group.Keywords: Mannich reaction, Carbonyl compound, Metal complexes, Biological activity.

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