International Journal of Immunological Nursing
Netherton Syndrome
Abstract
Netherton syndrome is a rarely found disorder which is inherited in an autosomal recessive pattern which consists of ichtchyosiform dermatosis, hair shaft abnormalities (trichorrhexis invaginata), and atopic diathesis. This disease results due to a mutation on chromosome 5q32 in a gene named SPINK5 (serine protease inhibitor, kazal type-5) which encodes inhibitors of serine proteases known as LEKTI.References (6)
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