Evaluation of Cytotoxic Activity of Cestrum nocturnum Leaves Extract against A549 Cell Line using MTT Assay

Prachi Sharma

International Journal of Plant Biotechnology

Evaluation of Cytotoxic Activity of Cestrum nocturnum Leaves Extract against A549 Cell Line using MTT Assay

Prachi Sharma

Abstract

Cancer remains a major global cause of death, necessitating ongoing research for effective treatments. Traditional herbal medicine is being explored for novel anti-cancer compounds. This study investigates the cytotoxic effects of Cestrum nocturnum ethanolic extract on A549 lung cancer cells, a type of non-small cell lung cancer (NSCLC). NSCLC is a significant health concern in India, affecting even non-smokers. Cestrum nocturnum, known as Night-blooming jasmine, has shown promise in inhibiting tumor growth in mice, and its active compound, apigenin, exhibits anti-cancer properties. Apigenin modulates epigenetic mechanisms involved in cancer development and progression, including DNA methylation, histone modification, signaling pathways, cell cycle arrest, and apoptosis. The ethanolic extract demonstrated concentration-dependent cytotoxicity, indicating potential anti-cancer properties. This study underscores Cestrum nocturnum's potential as an anti-cancer agent and provides insights into apigenin's mechanisms of action, warranting further research for therapeutic applications in NSCLC treatment.

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Evaluation of Cytotoxic Activity of Cestrum nocturnum Leaves Extract against A549 Cell Line using MTT Assay

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