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By: Stephen Monday, Atul Khajuria, Eric Kwasi Elliason, Gagan, and J. Samuel Kamanda
Among the Indian women, cervical cancer is still the second most prevalent cancer and one of the leading causes of cancer death especially in the rural areas where screening and diagnostic facilities are not developed. This study assesses the feasibility, awareness, and acceptability on the use of biofunctionalized nanoparticles for early detection of cervical cancer in women from rural North India. Using a pre-tested structured questionnaire, a community-based cross-sectional survey was conducted among 770 women aged 18-60 years from four rural districts in Uttar Pradesh and Haryana. The findings showed that 67.3% of the respondents had never undergone any form of cervical screening, however, a considerable 79.2% showed propensity towards undertaking a test that utilized nanotechnology if it was characterized as safe, accurate and non-invasive. Remarkably, the greater acceptance was noted among those with higher educational levels (p < 0.001). The findings highlight the necessity of developing appropriate targeted awareness programs but also suggest the possibilities of utilizing economic point-of-need nanodiagnostic devices in public health systems to increase cervical cancer detection and reduce mortality in such populations.
Keywords: Cervical cancer, biofunctionalized nanoparticles, nanotechnology, early detection, rural India, women’s health, public health diagnostics.
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Refrences:
- Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R. Cancer of the cervix uteri: 2021 update. Int J Gynaecol Obstet. 2021 Oct;155:28–44.
- Hakim RU, Amin T, Ul Islam SB. Advances and challenges in cervical cancer: From molecular mechanisms and global epidemiology to innovative therapies and prevention strategies. Cancer Control. 2025 Apr 14;32:10732748251336415.
- Yadav N, Dahiya T, Chhillar AK, Rana JS, Saini HM. Nanotechnology in cancer diagnostics and therapeutics: a review. Curr Pharm Biotechnol. 2022 Nov 1;23(13):1556–68.
- Kumar D, Dey T, Bansal P, Srinivasa GY, Rai B. Sociodemographic and clinical profile of geriatric patients with cervical cancer—An audit from a tertiary cancer center in India. J Family Med Prim Care. 2020 Mar 1;9(3):1528–32.
- Chozom T, Tshomo T, Modani A, Kakoti M, Nambiar D. Assessing the gender-responsiveness of Bhutan’s cervical cancer plan and related strategies. In: Handbook on Sex, Gender and Health: Perspectives from South Asia. Singapore: Springer Nature Singapore; 2025. p. 1015–36.
- Ghosh R, Ghosh P, Kar S, Mukherjee S, Sinha D. Green nanotechnology: the novel and emerging strategy for sustainable development. InSustainable nanomaterials for biosystems engineering 2023 May 4 (pp. 417-446). Apple Academic Press.
- Hegde MM, Sandbhor P, Gota V, Goda JS. Insight into lipid-based nanoplatform-mediated drug and gene delivery in neuro-oncology and their clinical prospects. Frontiers in Oncology. 2023 Jul 6;13:1168454.
- Kakotkin VV, Semina EV, Zadorkina TG, Agapov MA. Prevention strategies and early diagnosis of cervical cancer: current state and prospects. Diagnostics. 2023 Feb 7;13(4):610.
- Maitra S, Behera HC, Bose A, Chatterjee D, Bandyopadhyay AR. From cultural dispositions to biological dimensions: a narrative review on the synergy between oral health and vitamin D through the lens of Indian habitus. Frontiers in Oral Health. 2025 Apr 25;6:1569940.
- Kaur S. Barriers to consumption of fruits and vegetables and strategies to overcome them in low-and middle-income countries: a narrative review. Nutrition Research Reviews. 2023 Dec;36(2):420-47.
- Kakotkin VV, Semina EV, Zadorkina TG, Agapov MA. Prevention strategies and early diagnosis of cervical cancer: current state and prospects. Diagnostics. 2023 Feb 7;13(4):610.
- Bruni L, Serrano B, Roura E, Alemany L, Cowan M, Herrero R, Poljak M, Murillo R, Broutet N, Riley LM, de Sanjose S. Cervical cancer screening programmes and age-specific coverage estimates for 202 countries and territories worldwide: a review and synthetic analysis. The Lancet Global Health. 2022 Aug 1;10(8):e1115-27.
- Mehrotra R, Yadav K. Cervical cancer: formulation and implementation of Govt of India guidelines for screening and management. Indian Journal of Gynecologic Oncology. 2022 Mar;20:1-8.
- Burlec AF, Corciova A, Boev M, Batir-Marin D, Mircea C, Cioanca O, Danila G, Danila M, Bucur AF, Hancianu M. Current overview of metal nanoparticles’ synthesis, characterization, and biomedical applications, with a focus on silver and gold nanoparticles. Pharmaceuticals. 2023 Oct;16(10):1410.
- Maheshwari V, Girotra S, Malik M, Basu S. Prevalence and predictors of cervical cancer screening among married women in India: A cross-sectional analysis of National Family Health Survey-5 data. Cancer Research, Statistics, and Treatment. 2025 Jan 1;8(1):30-8.
- Sahasrabuddhe VV. Cervical cancer: Precursors and prevention. Hematology/Oncology Clinics. 2024 Aug 1;38(4):771-81.
- Kakotkin VV, Semina EV, Zadorkina TG, Agapov MA. Prevention strategies and early diagnosis of cervical cancer: current state and prospects. Diagnostics. 2023 Feb 7;13(4):610.
- Zhetpisbayeva I, Kassymbekova F, Sarmuldayeva S, Semenova Y, Glushkova N. Cervical cancer prevention in rural areas. Annals of Global Health. 2023 Nov 1;89(1):75.