This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.
Journal Menu
By: Allamsetti Yogesh, Pothamsetty kasi V. Rao, and B Vadiraj
1 PG Student, Department of Mechanical Engineering, Kluniversity, Vaddeswaram, Guntur, India
2 Associate Professor, Department Of Mechanical Engineering, Kluniversity, Vaddeswaram, Guntur, India
3 Research scholar , Department Of Mechanical Engineering, Kluniversity, Vaddeswaram, Guntur, India
Nanomaterials have significantly transformed the biomedical landscape, offering novel
solutions for diagnosis, treatment, and disease prevention. Their distinct physicochemical
characteristics such as a high surface area-to-volume ratio, tunable surface chemistry, and
improved bioavailability enable precise interactions with biological systems at the molecular
level. This review presents a comprehensive examination of the synthesis methods and
characterisation techniques employed to develop biomedical-grade nanomaterials, highlighting
their structural and functional optimisation for clinical applications. Key areas of application
discussed include targeted drug delivery systems, advanced imaging modalities, tissue
engineering scaffolds, and antimicrobial agents. The review also explores recent breakthroughs
in nanotechnology that have facilitated the transition of laboratory innovations into real-world
clinical settings, enhancing therapeutic efficacy and patient outcomes. Furthermore, it critically
evaluates the challenges hindering the widespread adoption of nanomaterials in medicine, such
as potential cytotoxicity, regulatory barriers, long-term biocompatibility, and issues related to
large-scale production. By integrating current research findings and clinical data, this article
aims to provide insights into the evolving role of nanomaterials in modern medicine and outlines future directions for overcoming existing limitations. In the final analysis, it emphasizes the necessity of interdisciplinary cooperation to guarantee the secure, moral, and efficient application of nanotechnology in healthcare.
Keywords: Nanomaterials, Biomedical Applications, Drug Delivery, Tissue Engineering,
Nanotechnology, Healthcare.
Citation:
Refrences:
1. Haleem A, Javaid M, Singh RP, Rab S, Suman R. Applications of nanotechnology in medical field: a brief review. Global Health Journal. 2023 Jun 1;7(2):70-7.
2. McNamara K, Tofail SA. Nanoparticles in biomedical applications. Advances in Physics: X. 2017 Jan 2;2(1):54-88.
3. Azadpour A, Khaleghi S. Biosynthesized nanoparticles in pharmaceutical and biomedical sciences: Recent advances. Materials Today Communications. 2024 Dec 1;41:110741.
4. Pijeira MS, Viltres H, Kozempel J, Sakmár M, Vlk M, İlem-Özdemir D, Ekinci M, Srinivasan S, Rajabzadeh AR, Ricci-Junior E, Alencar LM. Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology. EJNMMI Radiopharmacy and Chemistry. 2022 Apr 25;7(1):8.
5. Xu C, Zhang YS, Begin S, Thanh NT. Introduction to advanced functional nanomaterials for biomedical applications. Nanoscale. 2022;14(20):7441-3.
6. Zhao Y, Zhang Z, Pan Z, Liu Y. Advanced bioactive nanomaterials for biomedical applications. InExploration 2021 Dec (Vol. 1, No. 3, p. 20210089).
7. Mabrouk M, Das DB, Salem ZA, Beherei HH. Nanomaterials for biomedical applications: production, characterisations, recent trends and difficulties. Molecules. 2021 Feb 18;26(4):1077.
8. Alsuraifi A. Metallic nanoparticles in dental biomaterials: A review. International Journal of Medical Sciences. 2020 Jan 1;3(1):27-37.
9. Ashique S, Garg A, Mishra N, Raina N, Ming LC, Tulli HS, Behl T, Rani R, Gupta M. Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC). Naunyn-Schmiedeberg's Archives of Pharmacology. 2023 Nov;396(11):2769- 92.
10. Li Q, Shao X, Dai X, Guo Q, Yuan B, Liu Y, Jiang W. Recent trends in the development of hydrogel therapeutics for the treatment of central nervous system disorders. NPG Asia Materials. 2022 Dec;14(1):14.
11. Bennett NK, Chmielowski R, Abdelhamid DS, Faig JJ, Francis N, Baum J, Pang ZP, Uhrich KE, Moghe PV. Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity. Biomaterials. 2016 Dec 1;111:179-89.
12. Castner DG, Ratner BD. Biomedical surface science: Foundations to frontiers. Surface science. 2002 Mar 10;500(1-3):28-60.
13. Deng G, Li S, Sun Z, Li W, Zhou L, Zhang J, Gong P, Cai L. Near-infrared fluorescence imaging in the largely unexplored window of 900-1,000 nm. Theranostics. 2018 Jul 16;8(15):4116.
14. Du XJ, Wang JL, Iqbal S, Li HJ, Cao ZT, Wang YC, Du JZ, Wang J. The effect of surface charge on oral absorption of polymeric nanoparticles. Biomaterials science. 2018;6(3):642-50.
15. Teubl BJ, Meindl C, Eitzlmayr A, Zimmer A, Fröhlich E, Roblegg E. In‐vitro permeability of neutral polystyrene particles via buccal mucosa. Small. 2013 Feb 11;9(3):457-66.
16. Hogan KJ, Mikos AG. Biodegradable thermoresponsive polymers: Applications in drug delivery and tissue engineering. Polymer. 2020 Dec 21;211:123063.
17. Kaushik A, Jayant RD, Nikkhah-Moshaie R, Bhardwaj V, Roy U, Huang Z, Ruiz A, Yndart A, Atluri V, El-Hage N, Khalili K. Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers. Scientific reports. 2016 May 4;6(1):25309.
18. Kircher MF, De La Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nature medicine. 2012 May;18(5):829-34.
19. Zhang A, Jiang Y, Loh KY, Bao Z, Deisseroth K. Genetically targeted chemical assembly. Nature Reviews Bioengineering. 2024 Jan;2(1):82-94.
20. Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert LM. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science. 2020 Mar 20;367(6484):1372-6. 21. Du G, Hathout RM, Nasr M, Nejadnik MR, Tu J, Koning RI, Koster AJ, Slütter B, Kros A, Jiskoot W, Bouwstra JA. Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles. Journal of Controlled Release. 2017 Nov 28;266:109-18.
22. Malode SJ, Pandiaraj S, Alodhayb A, Shetti NP. Carbon nanomaterials for biomedical applications: progress and outlook. ACS applied bio materials. 2024 Jan 25;7(2):752- 77.\]
23. Singh S, Rai N, Tiwari H, Gupta P, Verma A, Kumar R, Kailashiya V, Salvi P, Gautam V. Recent advancements in the formulation of nanomaterials-based nanozymes, their catalytic activity, and biomedical applications. ACS applied bio materials. 2023 Aug 17;6(9):3577-99.
24. Baruah A, Newar R, Das S, Kalita N, Nath M, Ghosh P, Chinnam S, Sarma H, Narayan M. Biomedical applications of graphene-based nanomaterials: recent progress, challenges, and prospects in highly sensitive biosensors. Discover Nano. 2024 Jun 17;19(1):103.
25. Sahoo J, Sharma R, Pachauri V, Gandhi S. Biomimetic/Bioderived Nanoengineered Interfaces for Biosensor Applications: A Review. ACS Applied Nano Materials. 2024 Aug 23;7(17):19854-75.
26. Zhang X, Ma G, Wei W. Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application. NPG Asia Materials. 2021 Dec;13(1):52.
27. Khorsandi K, Hosseinzadeh R, Sadat Esfahani H, Keyvani-Ghamsari S, Ur Rahman S. Nanomaterials as drug delivery systems with antibacterial properties: current trends and future priorities. Expert Review of Anti-infective Therapy. 2021 Oct 3;19(10):1299-323. 28. Meng YQ, Shi YN, Zhu YP, Liu YQ, Gu LW, Liu DD, Ma A, Xia F, Guo QY, Xu CC, Zhang JZ. Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal of Nanobiotechnology. 2024 Jan 8;22(1):24.
29. Tang K, Xue J, Zhu Y, Wu C. Design and synthesis of bioinspired nanomaterials for biomedical application. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2024 Jan;16(1):e1914.
30. Bianchi M, Carnevale G. Innovative nanomaterials for biomedical applications. Nanomaterials. 2022 May 5;12(9):1561.
31. Wang D, Gu W, Chen W, Zhou J, Yu L, Kim BK, Zhang X, Kim JS. Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy. Coordination Chemistry Reviews. 2022 Dec 1;472:214788.
32. Solveyra EG, Thompson DH, Szleifer I. Proteins Adsorbing onto Surface-Modified Nanoparticles: Effect of Surface Curvature, pH, and the Interplay of Polymers and Proteins Acid–Base Equilibrium. Polymers. 2022 Feb 14;14(4):739.
33. Yadav KS, Jacob S, Pethe AM. Nanomaterials physics: A critical review. Photophysics and Nanophysics in Therapeutics. 2022 Jan 1:207-16.
34. Zhang X, Ma G, Wei W. Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application. NPG Asia Materials. 2021 Dec;13(1):52.
35. Khorsandi K, Hosseinzadeh R, Sadat Esfahani H, Keyvani-Ghamsari S, Ur Rahman S. Nanomaterials as drug delivery systems with antibacterial properties: current trends and future priorities. Expert Review of Anti-infective Therapy. 2021 Oct 3;19(10):1299-323. 36. Meng YQ, Shi YN, Zhu YP, Liu YQ, Gu LW, Liu DD, Ma A, Xia F, Guo QY, Xu CC, Zhang JZ. Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal of Nanobiotechnology. 2024 Jan 8;22(1):24.
37. Tang K, Xue J, Zhu Y, Wu C. Design and synthesis of bioinspired nanomaterials for biomedical application. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2024 Jan;16(1):e1914.
38. Bianchi M, Carnevale G. Innovative nanomaterials for biomedical applications. Nanomaterials. 2022 May 5;12(9):1561.
39. Wang D, Gu W, Chen W, Zhou J, Yu L, Kim BK, Zhang X, Kim JS. Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy. Coordination Chemistry Reviews. 2022 Dec 1;472:214788.
40. Abdelrahman EA, Basha MT. Facile synthesis and characterization of SrCO3/MgO/CaO/CaCO3 novel nanocomposite for efficient removal of crystal Violet dye from aqueous media. Inorganics. 2025 Apr 3;13(4):112.
41. Jain P, Jangid AK, Pooja D, Kulhari H. Design of manganese-based nanomaterials for pharmaceutical and biomedical applications. Journal of Materials Chemistry B. 2024;12(3):577-608.
42. Li L, Wang T, Zhong Y, Li R, Deng W, Xiao X, Xu Y, Zhang J, Hu X, Wang Y. A review of nanomaterials for biosensing applications. Journal of Materials Chemistry B. 2024;12(5):1168-93.
43. Walke S, Mandake M, Naniwadekar M. A Review of Recent Advancements and Perspectives of Nanotechnology in the Application of Biomedical Imaging and Instrumentation. Chemistryselect. 2024 Jul 18;9(27):e202304082.
44. Zhang D, Chen Y, Hao M, Xia Y. Putting hybrid nanomaterials to work for biomedical applications. Angewandte Chemie International Edition. 2024 Apr 15;63(16):e202319567.
45. Zhang Z, Yang S, Su H, Qian K. Porous Noble Metal‐Based Nanomaterials in Biomedical Applications. Advanced NanoBiomed Research. 2024 Feb;4(2):2300078.
46. Zhang Z, Yang S, Su H, Qian K. Porous Noble Metal‐Based Nanomaterials in Biomedical Applications. Advanced NanoBiomed Research. 2024 Feb;4(2):2300078.
47. Sahoo J, Sharma R, Pachauri V, Gandhi S. Biomimetic/Bioderived Nanoengineered Interfaces for Biosensor Applications: A Review. ACS Applied Nano Materials. 2024 Aug 23;7(17):19854-75.
48. Wang D, Gu W, Chen W, Zhou J, Yu L, Kim BK, Zhang X, Kim JS. Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy. Coordination Chemistry Reviews. 2022 Dec 1;472:214788.\
49. Solveyra EG, Thompson DH, Szleifer I. Proteins Adsorbing onto Surface-Modified Nanoparticles: Effect of Surface Curvature, pH, and the Interplay of Polymers and Proteins Acid–Base Equilibrium. Polymers. 2022 Feb 14;14(4):739.
50. Yadav KS, Jacob S, Pethe AM. Nanomaterials physics: A critical review. Photophysics and Nanophysics in Therapeutics. 2022 Jan 1:207-16.