By: Priyanka Kashid
Deogiri College, Chatrapati Sambhajinagar, Maharashtra
The study involved the synthesis and characterization of a novel bidentate Schiff base ligand, [(E)-2,4-dichloro-6-(1-((4-fluorophenyl) iminoethyl) phenol)], derived from 1-(3,5-dichloro-2-hydroxyphenyl) ethanone and 4-fluoroaniline. Transition metal salts (Co (II), Cu (II), Fe (II), Zn (II), Ni (II), Mn (II), Ag (II), Cd (II), Hg (II), and Pd (II)) were used to synthesize metal complexes. The chemicals used were of analytical grade, and solvents were distilled before use. Characterization involved UV, IR, and NMR spectroscopic techniques, alongside physical properties such as melting points. The ligand exhibited bidentate behavior with a ligand-to-metal ion stoichiometry of 2:1.UV-Visible spectrophotometry at 240 nm and FT-IR spectroscopy (400-4000 cm^-1) confirmed the successful synthesis of the ligand and metal complexes. NMR spectra recorded on a 500 MHz spectrophotometer further validated the structures. Thin layer chromatography (TLC) monitored reaction progress. The metal complexes exhibited characteristic bands indicating coordination between the metal ion and ligand atoms. Biological activity assays against various bacteria (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis) revealed significant antimicrobial activity for Cu (II) and Ni (II) complexes, surpassing that of standard drugs. The metal complexes showed varying degrees of activity against different bacterial strains.The synthesized ligand and metal complexes displayed promising antimicrobial properties, particularly Cu (II) and Ni (II) complexes. This research contributes to the understanding of Schiff base complexes as potential antibacterial agents.
Citation:
Refrences:
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