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By: Mukesh Chander and Lovejot Lovejot.
1. Professor (Assistant) & Dean Research (Former), Bioprocess Laboratory, P.G. Department of Biotechnology, Khalsa College (Autonomous), Amritsar.
2. Project Student, Bioprocess Laboratory, P.G. Department of Biotechnology, Khalsa College (Autonomous), Amritsar.
Tendon and tissue injuries are difficult to manage because of their poor natural healing ability and the risk of scar tissue and reinjury. Nanotechnology has created materials that can closely mimic natural biological structures, opening up new possibilities for regenerative medicine in recent years. In the creation of scaffolds and delivery systems for tissue repair, nanomaterials are very useful. The extracellular matrix’s nanoscale configuration is replicated using electrospun nanofiber scaffolds, which promote cell adhesion, proliferation, and alignment in patterns resembling those of healthy tendon tissue. Nanoparticles can also be incorporated into these scaffolds to release drugs or growth factors in a slow and targeted manner, supporting new blood vessel formation and reducing inflammation. The mechanical durability required for the restoration of load-bearing tissues is also supplied by composite scaffolds reinforced with ceramic, metallic, or carbon-based nanoparticles. According to lab tests, these methods help restore the bone-tendon link, increase tendon strength, and hasten healing. However, issues with cost, large-scale manufacturing, and long-term safety continue to restrict its wider clinical usage. Overall, by fusing biological support with synthetic strength, scaffolds based on nanomaterials present a promising avenue for enhanced therapeutics in tendon and tissue healing.
Bio composites, Drug delivery, Bionanocomposites, Tendon regeneration,
Scaffolds.
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