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22 articles for “low solubility”
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Nanosuspension-novel Technique for Solubility Enhancement
Abstract: In the treatment of many diseases, getting medicinal compounds to the desired location is a serious issue. Poor biodistribution, limited effectiveness, unfavorable side effects, and a lack of selectivity define traditional medication use. Different types of nanostructures are produced using various size reduction processes and technologies, each with its own set of physicochemical and biological features. These technologies make nanostructures a good material for biomedical applications, and they've gained a …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 7, Issue 2, 2021 · pp. 18–24 Read article
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Chitosan: Chemistry, Applications & Economics of Production - A Review
Abstract: Chitosan is a natural poly-cationic linear polysaccharide derived from chitin and also known as de-acetylated chitin. It is derived from partial de-acetylation of chitin. Its low solubility in neutral and alkaline solution limits its application. Chitosan’s chemical modification brings to it new reactive functional properties for different applications. Because of biocompatibility, non-toxicity, low allergenicity and biodegradability, it is used in various applications .This review paper presents the chemistry, literature review …
Published in International Journal of Analytical and Applied Chemistry · Vol. 2, Issue 1, 2016 · pp. 23–34 Read article
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Review Article on: Nanoemulsion based intranasal drug delivery to Brain
Abstract: The bloodbrain barrier (BBB) controls and restricts the entry of therapeutic medications because it plays a critical role in protecting the brain from toxins.Nasal medicine administration allows for immediate drug delivery into the brain through the nose-to brain pathway.avoiding both the first pass impact and the blood-brain barrier. Various novel and promising formulation approaches have been explored for drug targeting to the brain by nasal administration. Nanoemulsions have the potential …
Published in International journal of Nanobiotechnology · Vol. 10, Issue 1, 2024 · pp. 17–24 Read article
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Study on the Significance of Water Treatment Using Activated Carbon from Palm Bunch Fiber
Abstract: Activated carbon produced from palm bunch fibers was investigated for water treatment with the aim to improve water quality for industrial consumption and not for humans and animal consumption. Dominantly the activated carbon produced from palm bunch fiber was used for treatment of industrial effluent water and the application is environmental friendly. The high alkali concentration in the activated carbon improved the pH level of the treated water from 4.03 …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 6, Issue 1, 2020 · pp. 30–46 Read article
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Originative Approaches in Powder Formulation for Enhanced Therapeutic Efficacy
Abstract: Powder formulation is a cornerstone in the pharmaceutical industry, playing a vital role in improving drug efficacy and ensuring optimal therapeutic outcomes. However, traditional formulation methods often face significant challenges, such as poor solubility and low bioavailability, which can limit the effectiveness of many drugs. To address these issues, innovative strategies have emerged, including amorphous solid dispersions (ASDs), nanotechnology, and advanced manufacturing techniques like spray drying and hot melt etrusion. …
Published in International journal of Nanobiotechnology · Vol. 11, Issue 1, 2025 · pp. 1–10 Read article
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Modeling Fly Ash and Alccofine Partial Replacement of Concrete Density for High Strength Development
Abstract: This paper monitor the development of density from concrete model partially replaced cement with alccofine and fly ash, the study were generated applying modeling techniques, this concept were adopted to detail the influence of other concrete properties that influenced the growth rate of concrete density generated from such model concrete. Linear influences were observed in all the figures, the study observed variations of growth rate in the study, these are …
Published in International Journal of Sustainable Building Technology · Vol. 3, Issue 1, 2020 · pp. 29–48 Read article
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Isolation and Characterization of Rhizosphere-Competent Indigenous Phosphate-Solubilizing Bacteria for Biofertilizer Applications
Abstract: Phosphorus (P) is an essential nutrient for crop growth and development. Low levels of P in soil is due to high reactivity of soluble P with calcium (Ca), iron (Fe) or aluminum (Al) that lead to P precipitation. Mineral phosphate (P) solubilization is an important activity of rhizospheric bacteria that contribute significantly to the plant growth and development in eco-friendly manner. Four potent phosphate solubilizers (PSB-2, PSB-3, PSB-4 and PSB-7), …
Published in International Journal of Plant Biotechnology · Vol. 4, Issue 2, 2018 · pp. 13–18 Read article
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Effect of Plant Growth Regulator on Flowering and Yield Attributes of Litchi
Abstract: The study was carried out at the Horticulture Research Centre (HRC) Fruit Orchard, Regional Agricultural Research Station (RARS), Jamalpur, Bangladesh, during 2024–2025 to assess the influence of Plant Growth Regulator (PGR) (GA3) on flowering and yield attributes of litchi. The age of Litchi plants were 14–15 years old. The treatments are T1 = GA3 @ 50 mg/L on panicle before flower opening, T2 = GA3 @ 50 mg/L at 15 …
Published in International Journal of Plant Biotechnology · Vol. 12, Issue 1, 2026 · pp. 1–10 Read article
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Microstructure and Mechanical Behavior of Microalloyed Forging Steels
Abstract: The microalloyed (MA) forging steels have been developed over the past several decades and they are gradually employed in the high-performance applications in many structural, automotive, and numerous engineering applications. The principle of microalloying contents in the Fe–C alloy system, thereby preferably combined with different mechanical, heat treatment, and microalloying solubility control the precipitation behaviors that lead to enormous opportunities to develop a new generation of high strength low alloy …
Published in International Journal of Metallurgy and Alloys · Vol. 11, Issue 2, 2025 · pp. 1–14 Read article
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Isocoreopsin and Glycogen Phosphorylase – An in-silico Interaction Study: A New Way to Tackle Type 2 Diabetes (T2D)†
Abstract: The activity of glycogen phosphorylase (GP) plays a crucial role in regulating glycogen metabolism, and its excessive activity has been closely linked to the pathogenesis of metabolic disorders, such as type 2 diabetes (T2D). Therefore, targeting GP inhibition has emerged as a significant therapeutic strategy for managing this disease. Current research focuses on the discovery and development of novel small molecules capable of suppressing GP activity. Among these, flavonoids have …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 1, 2025 · pp. 76–80 Read article
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Assessing trends in Speciation of First-Row Transition Metals in Children's Playgrounds of Owerri, Nigeria
Abstract: Chemical species of metals affect toxicity but trends of these metals species in soils are less studied. This study examined the trends and variability of species of metals in soils from playgrounds within Owerri. Eighty-one composite soil samples from nine playgrounds were collected in dry and rainy season to reflect spatio-seasonal variability. Samples were characterized by standard methods in triplicates and then extracted sequentially. Concentrations of metal species were determined …
Published in International Journal of Green Chemistry · Vol. 11, Issue 1, 2025 · pp. 28–45 Read article
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Optimization Strategies Towards Enhanced Production of Microbial Surfactants for Diverse Industrial Applications: A Futuristic Approach
Abstract: Chemical or synthetic surfactants being employed in numerous industries pose significant environmental hazards due to their persistence in the environment and potential toxicity to aquatic life. Biosurfactants are low-molecular-weight surface-active compounds that offer a promising alternative to surfactants owing to their less toxicity, biodegradability and biocompatibility nature. They are derived from a variety of natural sources, including bacteria, fungi, and plants. In recent years, there has been a surge in …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 10, Issue 1, 2024 · pp. 11–22 Read article
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Sulfur-Based Copolymers: Current Status and NewOpportunities in Synthesis and Product Applications
Abstract: Sulfur-based copolymers are fascinating materials with a wide range of applications. This reviewarticle delves into the synthetic aspects of sulfur copolymers, their characteristics, and theirapplications. Sulfur is a byproduct of refineries, produced in large quantities worldwide. Varioussulfur-based copolymers have been synthesized through inverse vulcanization, catalyst-induced low temperature inverse vulcanization, and polycondensation reactions. Researchers have studied a varietyof monomers, including benzoxazine moieties and sulfur-based systems with allylic or vinylicfunctionalities. The article …
Published in International Journal of Polymer Science and Engineering · Vol. 11, Issue 1, 2025 · pp. 10–36 Read article
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Recent Trends in Production, Characterization, and Utilization of Fungal Chitosan
Abstract: Chitosan is the second most abundant biopolymer in nature after cellulose that can be extracted from marine sources, as well as from agricultural waste products such as mushrooms or other fungal sources following chitin deacetylation. The consistent production of these glycans by fungi is unaffected by seasonal changes, allowing for precise process control. This results in a more consistent quality of the final product. Currently, crustacean shells and other marine …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 10, Issue 1, 2024 · pp. 23–31 Read article
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Advancements of Carbon Quantum Dot and their use in Biomedical
Abstract: Carbon quantum dots (CQDs) have gained significant attention in the biomedical field due to their unique physicochemical properties and potential biomedical applications. In this review, we provide a comprehensive overview of recent advancements in CQD synthesis, functionalization, and their use in biomedical applications. Firstly, we discuss various synthetic methods used to produce CQDs, including microwave-assisted synthesis, hydrothermal synthesis, and electrochemical synthesis. Next, we delve into the functionalization of CQDs, which …
Published in International Journal of Nanomaterials and Nanostructures · Vol. 8, Issue 2, 2022 · pp. 28–33 Read article
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Emulsomes-based Formulations for Effective Delivery of Small Molecules: Recent Advances and Modern Applications Perspectives
Abstract: Oral administration is the simplest, most cost-effective, and most important form of medication delivery. As a result, scientists have faced difficulty in improving dosage formulations, particularly for the goal of extended-release. Vesicular drug delivery methods were created to address issues with medicines such as low bioavailability, protection from the hostile stomach environment, and protection against degrading gastric enzymes. Emulsomes were created as a new lipoidal vesicular system with an internal …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 7, Issue 1, 2021 · pp. 29–39 Read article
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Scleroglucan Production by Microbes and Downstream Processing
Abstract: Polymer based synthetic petroleum and plant natural polysaccharides do have the drawback of limited sources, as well as the latter's non-biodegradability. Eco-friendly, low-cost, and standardised microbial polysaccharides, on the other hand, offer a viable solution to this problem. They drew international recognition due to their original and distinctive physical and chemical propertiesas well as a diverse spectrum of industrial applications, the majority of which are rapidly becoming economically competitive. Scleroglucan, …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 8, Issue 1, 2022 · pp. 18–23 Read article
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General and Organic Chemistry Laboratory Experiments for Science, Pre-medical, and Pharmacy Students – Chapter V: Organic Synthesis
Abstract: Organic synthesis can be classified into many types, including simple one-step synthesis, multi-step, one-pot, microwave, or green synthesis. Each type of synthesis takes place through a specific pathway depending on reactants involved, the reaction conditions, the catalyst, the protection group, and the duration of the reaction. In some cases, the required compound can be prepared by more than one procedure, and an expert chemist prefers the procedure by which the …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 8–16 Read article
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Enhanced Recovery by Hydrotropes in Oxidized Coal Flotation
Abstract: AbstractSo far flotation proved its best in improving the concentration of low grade fines by recovering the maximum with the use of advanced flotation reagents. In this context we propose the process optimization with the use of hydrotropes as activators in the coal flotation process. It is observed that sodium benzoate a known hydrotrope helped in increasing the recovery of the concentrate percent from 12.8% at plant condition to 31% …
Published in International Journal of Renewable Energy and its Commercialization · Vol. 7, Issue 1, 2021 · pp. 19–23 Read article
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A Review Paper on Novel Lipid Nanoparticles for Enhanced Bioavailability of Bioactive Compounds in Breast Cancer Cell Lines
Abstract: Most bioactive compounds from natural products are heavily relied on drug development due to their biological, chemical and pharmacological properties. Some compounds exhibiting anticancer properties have also been reported. However, they present a challenge in achieving the effective absorption and delivery in the body. This is due to minimal bioavailability, fluctuation of plasma drug concentration, low tolerance, first-pass effect which leads to less desired efficacy. Therefore, this calls for an …
Published in International Journal of Composite and Constituent Materials · Vol. 10, Issue 1, 2024 · pp. 1–9 Read article