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By: Nicky Kumar Jaiswal, Ritik Pumba, and Reza Maaz
1Assistant Professor, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India.
2Student, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India
3Student, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India
Background: African Swine Fever (ASF) is a highly contagious and fatal viral disease caused by the ASF virus (ASFV) of the Asfarviridae family, affecting domestic pigs and wild boars. First identified in Kenya in 1921, ASF has spread globally, severely impacting the pork industry and causing significant financial losses. The virus transmits rapidly through direct or indirect contact, with arthropod vectors, wildlife reservoirs, and contaminated animal products playing key roles in its spread. Although ASF does not directly threaten human health, its effect on global trade and pig populations is devastating. Objective: This study aims to examine ASF transmission, economic consequences, and control strategies, emphasizing the lack of a vaccine or effective treatment. It highlights advancements in vaccine research, CRISPR-based gene editing, AI-driven surveillance, and blockchain technology as potential solutions to mitigate ASF’s impact. Methods: A comprehensive review of scientific literature and veterinary reports was conducted to assess ASF transmission patterns, clinical manifestations, and available containment measures. Research on modern diagnostic tools and technological innovations in disease management was also analyzed. Results: ASF continues to exhibit mortality rates exceeding 100%, with symptoms ranging from acute to chronic. Early detection, biosecurity measures, and culling infected animals remain crucial for disease containment. Advancements, like CRISPR-based gene editing and AI-driven surveillance, show promise, yet a commercially viable vaccine remains elusive. Conclusion: ASF remains a major challenge for the global swine industry, demanding coordinated efforts among governments, businesses, and research institutions. Investing in biosecurity and advanced surveillance technologies is essential to control ASF outbreaks and secure the future of pig farming worldwide.
Keywords: Asfarvirus. Hemorrhagic disease, Pigs/Swine, Contagious, Outbreak
Citation:
Refrences:
1. Njau EP, Machuka EM, Oduor B, Okoth EA. African swine fever virus (ASFV): Biology, genomics
and genotypes circulating in sub-Saharan Africa. Viruses. 2021;13(11):2285.
2. Schulz K, Staubach C, Blome S. African swine fever: Fast and furious or slow and steady? Viruses.
2019;11(9):866.
3. Schulz K, Staubach C, Blome S. African and classical swine fever: Similarities, differences and
epidemiological consequences. Vet Res. 2017;48(1):84.
4. Orosco F. Current progress in diagnostics, therapeutics, and vaccines for African swine fever virus.
Vet Integr Sci. 2023;21:1–16.
5. Fernandez-Colorado CP, Gomez-Guillen GE, Amparo AC, Estrella EE. African swine fever in the
Philippines: A review on surveillance, prevention, and control strategies. Animals (Basel).
2024;14(12):1512.
6. Tian X, Cramon-Taubadel S. Economic consequences of African swine fever. Nat Food.
2020;1:196–7.
7. Blome S, Franzke K, Beer M. African swine fever – A review of current knowledge. Virus Res.
2020;287:198099.
8. Sebina I, Pepper M. Humoral immune responses to infection: Common mechanisms and unique
strategies to combat pathogen immune evasion tactics. Curr Opin Immunol. 2018;51:46–54.
9. Jori F, Etter E, Kyalo D, Munstermann S, Dione M, Ouma E, et al. Wildlife-livestock interactions
in animal production systems: What are the biosecurity and health implications? Anim Front.
2021;11(5):8–19.
10. Yamauchi Y, Greber UF. Principles of virus uncoating: Cues and the snooker ball. Traffic.
2016;17(6):569–92.
11. Carapetis JR, Beaton A, Cunningham MW, Guilherme L, Karthikeyan G, Mayosi BM, et al. Acute
rheumatic fever and rheumatic heart disease. Nat Rev Dis Primers. 2016;2:15084.
12. Cochran HJ, Ssematimba A, Morrison RB, Dee SA, Diel DG. African swine fever: A review of
current disease management strategies and risks associated with exhibition swine in the United
States. Animals. 2023;13(23):3713.
13. Jori F, Etter E, Dione M, Ravaomanana J, Vial L. An updated review of Ornithodoros ticks as
reservoirs of African swine fever in sub-Saharan Africa and Madagascar. Pathogens.
2023;12(3):469.
14. Craig AF. Interrelationships of warthogs (Phacochoerus africanus), Ornithodoros ticks and African
swine fever virus in South Africa [thesis]. Pretoria: University of Pretoria; 2022.
15. Pereira De Oliveira R, Hutet E, Duhayon M, Guionnet JM, Paboeuf F, Dorsselaer A, et al.
Differential vector competence of Ornithodoros soft ticks for African swine fever virus: What if it
involves more than just crossing organic barriers in ticks? Parasites Vectors. 2020;13:1–15.
16. Ezzatpanah H, Asadi G, Moshari A, Goli M, Ghanbarpour A, Yousefi M, et al. Risks and new
challenges in the food chain: Viral contamination and decontamination from a global perspective.
Compr Rev Food Sci Food Saf. 2022;21(2):868–903.
17. Ruedas-Torres I, Thi to Nga B, Salguero FJ. Pathogenicity and virulence of African swine fever
virus. Virulence. 2024;15(1):2375550.
18. Hasahya E, Namukasa A, Okwee-Acai J, Barasa M, Otim C. Herd health management training
manual for animal health care workers. 2023.
19. World Health Organization, World Organisation for Animal Health. Implementing National
Bridging Workshop roadmaps for One Health collaboration: Successes and challenges from 17
countries. Geneva: WHO; 2024.
20. Kalmar ID, Cay AB, Tignon M. Sensitivity of African swine fever virus (ASFV) to heat, alkalinity
and peroxide treatment in presence or absence of porcine plasma. Vet Microbiol. 2018;219:144–9.
21. Liu Y, Zhang X, Li Y, Zhao D, Wang J, Wang X, et al. Prevention and control strategies of African
swine fever and progress on pig farm repopulation in China. Viruses. 2021;13(12):2552.
22. Hamrick B, Davis A, Miller J. Managing an invasion: Effective measures to control wild pigs.
Wildlife Prof. 2011;Summer:41–2.
23. Plut J, Petrovic T, Velhner M, Stanojevic D, Zoric M, Polaček V, et al. Risk factor impact on African
swine fever transmission in different extensive pig production settings in Serbia. Viruses.
2023;15(6):1264.
24. Yoo D, Kim Y, Choi Y, Jung K. African swine fever: Etiology, epidemiological status in Korea, and
perspective on control. J Vet Sci. 2020;21(2):e38.
25. Ahsan MM, Luna SA, Siddique Z. Machine-learning-based disease diagnosis: A comprehensive
review. Healthcare (Basel). 2022;10(3):541.
26. Kim YJ, Park B, Kang HE. Control measures to African swine fever outbreak: Active response in
South Korea, preparation for the future, and cooperation. J Vet Sci. 2021;22(1):e13.
27. Bergmann H, Schulz K, Conraths FJ. A review of environmental risk factors for African swine fever
in European wild boar. Animals (Basel). 2021;11(9):2692.
28. Hsu JC-H, Mangulabnan AF, Gallardo C, Salguero FJ. Factors affecting the spread, diagnosis, and
control of African swine fever in the Philippines. Pathogens. 2023;12:1068.
29. Beltrán-Alcrudo D, Arias M, Gallardo C, Kramer S, Penrith ML. African swine fever: Detection
and diagnosis – A manual for veterinarians. Rome: FAO; 2017. 92 p. (FAO Animal Production and
Health Manual; no. 19).
30. Okumu W. Border management and security in Africa. 2011.
31. Sun S, Zhang Z, Sinha R, Karni R, Krainer AR. SF2/ASF autoregulation involves multiple layers
of post-transcriptional and translational control. Nat Struct Mol Biol. 2010;17(3):306–12.
32. Vigfússon K, Johannsdottir L, Olafsson S. Obstacles to strategy implementation and success
factors: A review of empirical literature. Strategic Management. 2021;26:12–30.
33. Auplish A, Duong HT, Tran HTT, Nguyen TM. Capacity and needs assessment of veterinary
services in Vietnam in biosecurity, biosafety and One Health. PLoS One. 2024;19:e0295898.
34. Orosco FL. Host immune responses against African swine fever virus: Insights and challenges for
vaccine development. Open Vet J. 2023;13(12):1517.
35. Fan J, Li Y, Gao Y, Li Z, Zhao D. Attenuated African swine fever viruses and the live vaccine
candidates: A comprehensive review. Microbiol Spectr. 2024;12(11):e03199–23.
36. Teklue T, Sun Y, Luo Y, Wu X, Chen T, Zhang Y, et al. Current status and evolving approaches to
African swine fever vaccine development. Transbound Emerg Dis. 2020;67(2):529–42.
37. Kamboj A, Verma N, Mahajan V, Sood N, Sharma A. A comprehensive review of our understanding
and challenges of viral vaccines against swine pathogens. Viruses. 2024;16(6):833.
38. Wang Z, Lu M, Liu J, Jin X, Yang M. Immune escape mechanism and vaccine research progress of
African swine fever virus. Vaccines. 2022;10(3):344.
39. Hassan YM, El-Sherif M, Al-Dulaijan N, Al-Mutairi R, Alghamdi A, Abu El-Enin M. Recent
developments and future directions in point-of-care next-generation CRISPR-based rapid
diagnosis. Clin Exp Med. 2025;25(1):1–15.
40. Paul F, William M. The future of cloud security: AI-powered predictive analytics for proactive
threat management. 2023 Dec.
41. Ranjan P. AI-driven pig monitoring system: Behavior and weight analysis [master’s thesis].
Blacksburg (VA): Virginia Polytechnic Institute and State University; 2024. 86 p.
42. Söllner J-H. An experimental approach of an in vivo pathogen genome targeting strategy to generate
African swine fever resistant pigs [dissertation]. Hannover: Tierärztliche Hochschule Hannover;
2022. xii, 86 p.
43. Rezapour B, Musavi SJ, Maleki FS. The novel coronavirus 2019 (COVID-19): A narrative review.
Int J Coronaviruses. 2020;1(2):15–52.
44. Bremang A, Deka RP, Lindahl J, Singh VP, McGrane J. Guidelines for African swine fever (ASF)
prevention and control in smallholder pig farming in Asia: Farm biosecurity, slaughtering and
restocking. Rome: FAO; 2022. 60 p. (FAO Animal Production and Health Guidelines; no. 33).
