A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief

Volume: 11 | Issue: 01 | Year 2025 | Subscription
International Journal of Analytical and Applied Chemistry
Received Date: 01/28/2025
Acceptance Date: 02/07/2025
Published On: 2025-02-07
First Page: 50
Last Page: 56

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By: sowby jan, Dr. Dawood, Dr. Faizan, and Tahseen Irshad

Assistant professor, St. Soldier Group of Institutions, Jalandhar (Punjab, INDIA)
Guide, Saraswati Group of Colleges, Mohali, Ludhiana – Chandigarh NH, Gharuan, Punjab, India

Abstract

Despite advancements reducing mortality rates, adverse effects such as pain, nausea, and vomiting remain prevalent and can hinder recovery. Pain is now considered the fifth vital sign, as defined by the International Association for the Study of Pain, and inadequate pain management can result in prolonged hospital stays, increased drug use, and delayed recovery. Effective postoperative pain control is crucial in preventing respiratory complications and facilitating early discharge and return to daily activities. The severity and nature of pain vary depending on the type and location of surgery, with thoracic and abdominal procedures often associated with higher pain levels. Fear and anxiety further exacerbate discomfort, leading to muscle tension around the surgical site. Strategic pain management aims to minimize complications, promote early mobilization, and ensure a smooth recovery. Anesthesiologists, with their expertise in pharmacology and pain pathways, play a critical role in postoperative pain control by addressing both spinal and supra-spinal components of pain perception. Peripheral nociceptors initiate pain signals that are processed in the spinal cord, highlighting the complexity of pain mechanisms and the need for targeted analgesic interventions. Postoperative pain management is a critical aspect of patient recovery, with pharmacological interventions playing a key role in ensuring effective pain relief. The chemical properties and pharmacokinetics of analgesic drugs such as paracetamol and diclofenac are crucial in determining their efficacy and safety profiles. Paracetamol (C₈H₉NO₂), an aniline analgesic, acts primarily by inhibiting cyclooxygenase (COX) enzymes in the central nervous system, reducing prostaglandin synthesis and modulating pain perception. Diclofenac (C₁₄H₁₁Cl₂NO₂), a non-steroidal anti- inflammatory drug (NSAID), inhibits COX-1 and COX-2 enzymes, offering potent anti- inflammatory and analgesic effects. The solubility, bioavailability, and metabolic pathways of these drugs significantly impact their therapeutic outcomes. Proper understanding of their chemical interactions, such as protein binding and hepatic metabolism, is essential for optimizing their use in postoperative pain management

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Citation:

How to cite this article: sowby jan, Dr. Dawood, Dr. Faizan, and Tahseen Irshad, A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief. International Journal of Analytical and Applied Chemistry. 2025; 11(01): 50-56p.

How to cite this URL: sowby jan, Dr. Dawood, Dr. Faizan, and Tahseen Irshad, A Comparative Study of Intravenous Paracetamol and Intravenous Diclofenac for Post-operative Pain Relief. International Journal of Analytical and Applied Chemistry. 2025; 11(01): 50-56p. Available from:https://journalspub.com/publication/ijaac/article=14963

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