Synthesis, Characterization, Chromatographic and Antifungal Evaluation of New Chalcone-Azo Ligand and Complexes

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Volume: 12 | Issue: 01 | Year 2026 | Subscription
International Journal of Analytical and Applied Chemistry
Received Date: 01/15/2026
Acceptance Date: 02/02/2026
Published On: 2026-02-03
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By: Safa Saleem Zayed and Fatima Fahim Abd

1,2 Lecturer., Department of Chemistry, College of Education for Girls, University of Kufa, Iraq.

Abstract

Ligand chemistry is fundamental to coordination chemistry, complex chemistry, analytical reagents, and
the treatment of heavy ion pollutants. Recently, ligand complexes have been used in biological
applications such as radiation and the treatment of certain types of tumors. Researchers have expanded
their studies to include complexes such as nanomaterials and drug carriers, demonstrating their
effectiveness through their nanoscale properties. It is worth noting that we chose indole and linked it to a
chalcone group to enhance its activity and applications. The chalcone group contains a carbonyl group
and an unsaturated alkene group with a sequential pattern, making it highly stable. It was also linked to a
two-nitrogen azo bridge group, which includes electron pairs, further increasing its efficiency and
applications., They are primarily synthesized via the Claisen-Schmidt condensation, a reaction between an
aromatic aldehyde and an acetophenone in an alkaline or acidic medium, due to the restricted rotation
around the double bond, chalcones predominantly exist in the thermodynamically stable E-configuration,
which facilitates a planar structure optimal for electronic conjugation., Chromatographic separation is
considered one of the best methods in analytical chemistry for achieving high purity in separation, as it
relies on the molecular weight of the compound, the functional groups, interactions, and polarity of the
functional groups within a single compound. This allowed us to prepare a new ligand, which was then
synthesized with cadmium (Cd) and divalent zinc (Zn) ions. Its diagnostic spectra and antifungal activity
against two types of fungi were studied, followed by an investigation of its chromatographic behavior.

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How to cite this article: Safa Saleem Zayed and Fatima Fahim Abd, Synthesis, Characterization, Chromatographic and Antifungal Evaluation of New Chalcone-Azo Ligand and Complexes. International Journal of Analytical and Applied Chemistry. 2026; 12(01): -p.

How to cite this URL: Safa Saleem Zayed and Fatima Fahim Abd, Synthesis, Characterization, Chromatographic and Antifungal Evaluation of New Chalcone-Azo Ligand and Complexes. International Journal of Analytical and Applied Chemistry. 2026; 12(01): -p. Available from:https://journalspub.com/publication/ijaac/article=23557

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