Liquid-Liquid Extraction Strategies for the Isolation of Bioactive Heterocyclic Compounds

Volume: 11 | Issue: 01 | Year 2025 | Subscription
International Journal of Chemical Separation Technology
Received Date: 02/04/2025
Acceptance Date: 02/11/2025
Published On: 2025-02-19
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By: Neha Sahu

1. Neha Sahu, Department of Chemistry School of Basic & Applied Sciences, Lingaya’sVidyapeeth, Faridabad, Haryana Affiliation & Designation: Research Scholar

Abstract

Liquid-liquid extraction (LLE) is a widely employed technique for the isolation of bioactive heterocyclic compounds from natural products, fermentation broths, and synthetic mixtures. The efficiency of LLE depends on several factors, including solvent selection, pH manipulation, salting-out effects, and temperature control. Conventional solvent systems, such as water-organic solvent pairs, are commonly used, while advanced strategies, including ionic liquids (ILs), deep eutectic solvents (DESs), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE), have been developed to enhance selectivity and yield. Sequential and countercurrent LLE methods further improve the fractionation of complex mixtures. This review highlights key LLE strategies, emphasizing their optimization for the selective extraction of bioactive heterocyclic compounds, with a focus on green and sustainable approaches. Liquid-liquid extraction (LLE) is a crucial technique for isolating bioactive heterocyclic compounds from natural products, fermentation broths, and synthetic mixtures. Its efficiency depends on solvent selection, pH manipulation, and extraction optimization. Traditional water-organic solvent systems remain widely used, while green alternatives like ionic liquids (ILs) and deep eutectic solvents (DESs) enhance sustainability. Advanced techniques, including ultrasound-assisted (UAE) and microwave-assisted extraction (MAE), improve selectivity and yield. LLE applications span pharmaceuticals, nutraceuticals, food, and environmental industries. Future research aims to optimize LLE conditions, integrate advanced purification methods, and expand eco-friendly solvent use for sustainable bioactive compound isolation.

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Citation:

How to cite this article: Neha Sahu, Liquid-Liquid Extraction Strategies for the Isolation of Bioactive Heterocyclic Compounds. International Journal of Chemical Separation Technology. 2025; 11(01): -p.

How to cite this URL: Neha Sahu, Liquid-Liquid Extraction Strategies for the Isolation of Bioactive Heterocyclic Compounds. International Journal of Chemical Separation Technology. 2025; 11(01): -p. Available from:https://journalspub.com/publication/ijcst/article=15540

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