Supercritical Fluid Extraction: Mechanisms, Applications, and Recent Developments

Volume: 11 | Issue: 01 | Year 2025 | Subscription
International Journal of Chemical Separation Technology
Received Date: 01/30/2025
Acceptance Date: 02/09/2025
Published On: 2025-02-17
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By: Rakshita Chaudhary, Rachna, and Aditi

1Rakshita Chaudhary, Technical Data Associate, Central Drugs Standard Control Organisation, FDA Bhawan, ITO, Kotla Marg, New Delhi, India- 110002
2Rachna*, Sr. Technical Data Associate, Central Drugs Standard Control Organisation FDA Bhawan, ITO, Kotla Marg, New Delhi, India- 110002
3Aditi, Sr. Technical data associate at central drugs standard control organisation, FDA Bhawan, ITO, Kotla Marg, New Delhi, India- 110002

Abstract

Supercritical Fluid Extraction (SFE) is an advanced and versatile separation technique that harnesses the unique properties of supercritical fluids (SCFs) to extract a wide variety of compounds from both solid and liquid matrices. Supercritical fluids, which are substances at a temperature and pressure above their critical points, possess both liquid-like density and gas-like viscosity, making them highly effective solvents for extraction processes. This review delves into the underlying mechanisms of SFE, focusing on how SCFs interact with target compounds to achieve efficient and selective extractions. A key advantage of SFE is its ability to achieve high extraction yields with minimal solvent use, enhancing both efficiency and sustainability. The process also allows for the extraction of thermally sensitive compounds without degradation, which is crucial in industries such as food, pharmaceuticals, and cosmetics. The review highlights the broad range of applications for SFE, including the extraction of essential oils, active pharmaceutical ingredients, and natural products. Recent advancements in SFE technology are also discussed, with particular attention given to innovations that have improved extraction efficiency and selectivity. These include the use of novel supercritical fluids, such as carbon dioxide, and the integration of SFE with other separation techniques, such as chromatography. The optimization of operational parameters, such as temperature, pressure, and flow rate, is another critical area of development that has enhanced the scalability and adaptability of the SFE process. Looking ahead, the review explores future trends in SFE, emphasizing the continued development of environmentally friendly supercritical fluids and the increasing use of SFE in combination with other green extraction methods. The integration of these innovations promises to further improve the sustainability, efficiency, and versatility of SFE, expanding its application across various industries and disciplines.

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How to cite this article: Rakshita Chaudhary, Rachna, and Aditi, Supercritical Fluid Extraction: Mechanisms, Applications, and Recent Developments. International Journal of Chemical Separation Technology. 2025; 11(01): -p.

How to cite this URL: Rakshita Chaudhary, Rachna, and Aditi, Supercritical Fluid Extraction: Mechanisms, Applications, and Recent Developments. International Journal of Chemical Separation Technology. 2025; 11(01): -p. Available from:https://journalspub.com/publication/ijcst/article=15545

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