Nanocarrier Technologies of the Lemon Essential Oils: Brief Review

Volume: 11 | Issue: 1 | Year 2025 | Subscription
International Journal of Environmental Chemistry
Received Date: 10/29/2024
Acceptance Date: 12/20/2024
Published On: 2025-01-21
First Page: 20
Last Page: 33

Journal Menu


By: Livia Maria S. de Lima, Jéssica M. Pereira, Thaís Karine de L. Rezende, Olagide Wagner de Castro, and Anielle Christine A. Silva.

1–2Graduate Student, Strategic Materials Laboratory, Institute of Pharmaceutical Sciences, Federal University of Alagoas, Maceió, Alagoas, Brazil.
3Doctoral Student, Chemistry Institute, Uberlândia Federal University, Uberlândia, Minas Gerais, Brazil.
4Research Professor, Department of Physiology and Pharmacology, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceio, Brazil.
5Research Professor, Rede Nordeste De Biotecnologia (RENORBIO), Chemistry Institute, Federal University of Alagoas, Maceió, Alagoas, Brazil.

Abstract

This review article delves into integrating nanoparticles with essential oils, focusing on lemon essential oil (LEO) and recent advancements in nanocarrier technologies and their biotechnological applications. It systematically outlines the methodologies for synthesizing various nanostructured systems, including liposomes, solid lipid nanoparticles (SLNs), and nanoemulsions, emphasizing their critical role in enhancing the bioactivity of LEO. Moreover, the review provides a comprehensive analysis of the advantages and limitations of each nanocarrier type, offering valuable insights into their applications in drug delivery, food safety, and cosmetic formulations. The geographical distribution of research initiatives highlights a growing global interest in leveraging LEO’s potential within nanotechnology, paving the way for innovative solutions in personalized medicine and targeted therapy. In conclusion, the review calls for further investigation into these technologies to fully unlock their potential across diverse fields.

Loading

Citation:

How to cite this article: Livia Maria S. de Lima, Jéssica M. Pereira, Thaís Karine de L. Rezende, Olagide Wagner de Castro, and Anielle Christine A. Silva Nanocarrier Technologies of the Lemon Essential Oils: Brief Review. International Journal of Environmental Chemistry. 2025; 11(1): 20-33p.

How to cite this URL: Livia Maria S. de Lima, Jéssica M. Pereira, Thaís Karine de L. Rezende, Olagide Wagner de Castro, and Anielle Christine A. Silva, Nanocarrier Technologies of the Lemon Essential Oils: Brief Review. International Journal of Environmental Chemistry. 2025; 11(1): 20-33p. Available from:https://journalspub.com/publication/ijec/article=14610

Refrences:

  1. Uçar Y. Antioxidant Effect of Nanoemulsions Based on Citrus Peel Essential Oils: Prevention of Lipid Oxidation in Trout. Euro J Lipid Sci Technol. 2020;122(5). https://doi.org/10.1002/ejlt.201900405.
  2. Rombolà L, Scuteri D, Adornetto A, Straface M, Sakurada T, Sakurada S, et al. Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats. Evid-Based Complement Alternat Med. 2019. https://doi.org/10.1155/2019/2156873.
  3. Rajkumar V, Gunasekaran C, Paul CA, Dharmaraj J. Development of encapsulated peppermint essential oil in chitosan nanoparticles: Characterization and biological efficacy against stored-grain pest control. Pestic Biochem Physiol. 2020;170,104679. https://doi.org/10.1016/j.pestbp.2020.104679.
  4. Sharma S, Mulrey L, Byrne M, Jaiswal AK, Jaiswal S. Encapsulation of Essential Oils in Nanocarriers for Active Food Packaging. Foods. 2022;11(15):2337. https://doi.org/10.3390/foods11152337.
  5. Sanei-Dehkordi A, Moemenbellah-Fard MD, Saffari M Zarenezhad E, Osanloo M. Nanoliposomes containing limonene and limonene-rich essential oils as novel larvicides against malaria and filariasis mosquito vectors. BMC Complement Med Ther. 2022;22(1). https://doi.org/10.1186/s12906-022-03624-y.
  6. Yousefian Rad E, Homayouni Tabrizi M, Ardalan P, Seyedi SMR, Yadamani S, Zamani-Esmati et al. Citrus lemon essential oil nanoemulsion (CLEO-NE), a safe cell-depended apoptosis inducer in human A549 lung cancer cells with anti-angiogenic activity. J Microencapsul. 2020;37(5):394–402. https://doi.org/10.1080/02652048.2020.1767223.
  7. Tomar O, Akarca G. Effects of Ice Cream Produced with Lemon, Mandarin, and Orange Peel Essential Oils on Some Physicochemical, Microbiological and Sensorial Properties. Kocatepe Veterinary J. 2019:1–1. https://doi.org/10.30607/kvj.499415.
  8. Isalomboto Nkanga C, Murhimalika Bapolisi A, Ikemefuna Okafor N, Werner Maçedo Krause R. General Perception of Liposomes: Formation, Manufacturing and Applications. In Liposomes – Advances and Perspectives. IntechOpen. 2019. https://doi.org/10.5772/intechopen.84255.
  9. Aizik G, Waiskopf N, Agbaria M, Ben-David-Naim M, Levi-Kalisman Y, Shahar A Banin U, Golomb G. Liposomes of Quantum Dots Configured for Passive and Active Delivery to Tumor Tissue. Nano Letters. 2019;19(9):5844–5852. https://doi.org/10.1021/acs.nanolett.9b01027.
  10. Bertuzzi Gianluigi, Tirillini, Bruno, Angelini, Paola,Venanzoni, Roberto. Antioxidative Action of Citrus limonum Essential Oil on Skin. Euro J Med Plants. 2013;3:1–9.
  11. Gurunathan S, Jeyaraj M, Kang MH, Kim JH. Tangeretin-assisted platinum nanoparticles enhance the apoptotic properties of doxorubicin: Combination therapy for osteosarcoma treatment. Nanomater. 2019;9(8). https://doi.org/10.3390/nano9081089.
  12. Yusuf A, Casey A. (2020). Liposomal encapsulation of silver nanoparticles (AgNP) improved nanoparticle uptake and induced redox imbalance to activate caspase-dependent apoptosis. Apoptosis. 2020;25:1–2:120–134. https://doi.org/10.1007/s10495-019-01584-2.
  13. Fathy MM, Fahmy HM, Balah AMM, Mohamed FF, Elshemey WM. Magnetic nanoparticles-loaded liposomes as a novel treatment agent for iron deficiency anemia: In vivo study. Life Sci. 2019:234. https://doi.org/10.1016/j.lfs.2019.11678.
  14. Palmas L, Aroffu M, Petretto GL, Escribano-Ferrer E, Díez-Sales O, Usach I, et al. Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases. Pharma. 2020;13(9):216. https://doi.org/10.3390/ph13090216.
  15. Zaki S, Raslan M, El-Gendy A, El-dek S. (2022). Synthesis and characterization of lemon essential oil nanoliposomes as potential antimicrobial agents. Egypt J Chem. 2022;0(0):0–0. https://doi.org/10.21608/ejchem.2022.148471.6421.
  16. Maheshwari S, Singh A, Mahshwari S. Development and Evaluation of Topical Liposomal gel of Lemon Oil and Orange Oil for Synergistic Effect to Enhance Skin Beauty. 2023;14(2). https://www.ijppronline.com/index.php/IJPPR/article/view/283.
  17. Alikhani-Koupaei M. Liposome-entrapped essential oils on in vitro and in vivo antioxidant activity in leafy vegetables. Qual Assur Saf Crops Foods. 2015;7(3):369–373. https://doi.org/10.3920/QAS2013.0298.
  18. Hasani S, Ojagh SM, Ghorbani MR, Hasani M. Nano-Encapsulation of Lemon Essential Oil Approach to Reducing the Oxidation Process in Fish Burger during Refrigerated Storage. 2020.
  19. Ehsanfar P, Teimouri M, Pooladi M. Investigating Characterizations and Antifungal Effects of Solid Lipid Nanoparticles (SLNs) Loaded with Essential Oil of Citrus Aurantifolia on Isolated Malassezia Strains. Arch Adv Biosci. 2020;11(3):43–55. https://doi.org/10.22037/aab.v11i3.31259.
  20. Doğan N, Doğan C, Eticha AK, Gungor M, Akgul Y. Centrifugally spun micro-nanofibers based on lemon peel oil/gelatin as novel edible active food packaging: Fabrication, characterization, and application to prevent foodborne pathogens E. coli and S. aureus in cheese. Food Control. 2022;139: 109081. https://doi.org/10.1016/j.foodcont.2022.109081.
  21. Jiang T, Wang C, Liu W, Li Y, Luan Y, Liu P. (2021). Optimization and characterization of lemon essential oil entrapped from chitosan/cellulose nanocrystals microcapsules. J Appl Polym Sci. 2021;138(43). https://doi.org/10.1002/app.51265.
  22. Yazgan H, Ozogul Y, Kuley E. Antimicrobial influence of nanoemulsified lemon essential oil and pure lemon essential oil on food-borne pathogens and fish spoilage bacteria. Int J Food Microbiol. 2019:306. https://doi.org/10.1016/j.ijfoodmicro.2019.108266.
  23. Durmus M. The effects of nanoemulsions based on citrus essential oils (orange, mandarin, grapefruit, and lemon) on the shelf life of rainbow trout ( Oncorhynchus mykiss ) fillets at 4 ± 2°C. J Food Safety. 2019. https://doi.org/10.1111/jfs.12718.
  24. Meng F-B, Gou Z-Z, Li Y-C, Zou L-H, Chen W-J, Liu D-Y. The Efficiency of Lemon Essential Oil-Based Nanoemulsions on the Inhibition of Phomopsis sp. and Reduction of Postharvest Decay of Kiwifruit. Foods. 2022;11(10):1510. https://doi.org/10.3390/foods11101510.
  25. Liu T, Gao Z, Zhong W, Fu F, Li G, Guo J, et al. Preparation, Characterization, and Antioxidant Activity of Nanoemulsions Incorporating Lemon Essential Oil. Antioxidants. 2022;11(4):650. https://doi.org/10.3390/antiox11040650.
  26. Santos J, Alfaro-Rodríguez M-C, Vega L Muñoz J (2023). Relationship between HLB Number and Predominant Destabilization Process in Microfluidized Nanoemulsions Formulated with Lemon Essential Oil. Appl Sci. 2023;13(8):5208. https://doi.org/10.3390/app13085208.
  27. Galindo-Pérez MJ, Martínez-Acevedo L, Vidal-Romero G, Serrano-Mora LE, Zambrano-Zaragoza MdlL. Preservation of Fresh-Cut ‘Maradol’ Papaya with Polymeric Nanocapsules of Lemon Essential Oil or Curcumin. Polym. 2023;15(17):3515. https://doi.org/10.3390/polym15173515.
  28. Mosa Walid FA, Mackled Marwa I, Abdelsalam Nader R, Behiry Said I, Al-Askar Abdulaziz A, Basile Adriana, et al. Impact of Silver Nanoparticles on Lemon Growth Performance: Insecticidal and Antifungal Activities of Essential Oils From Peels and Leaves. Front Plant Sci. 2022;13. DOI: 10.3389/fpls.2022.898846.
  29. Vankar PS, Shukla D. Biosynthesis of silver nanoparticles using lemon leaves extract and its application for antimicrobial finish on fabric. Appl Nanosci. 2011;2(2):163–168. https://doi.org/10.1007/s13204-011-0051-y.
  30. Ismaail N Jasim, Estabraq AR Al-Wasiti, Ban H Adil (2023). The Impact of Gold Nanoparticles Synthesized by Essential Oil of Lemon and Plasma Jet Scheme on Growth Inhibition of Breast Cancer Cells. Plasma Med. 2023;13(41):31–40. DOI: 10.1615/PlasmaMed.2023051360.
  31. El-Gebaly AS, Sofy AR, Hmed AA, Youssef AM. Combination of nanoparticles (NPs) and essential oils (EOs) as promising alternatives to non-effective antibacterial, antifungal and antiviral agents: A Review. Biocatal Agric Biotechnol. 2024:103067–103067. https://doi.org/10.1016/j.bcab.2024.103067.
  32. Farooq S, Zainab Ngaini. Lemongrass and Lemon Monometallic and Bimetallic Nanoparticles Synthesis and Their Applications. Chem Africa. 2023;7(2):565–581. https://doi.org/10.1007/s42250-023-00797-y.
  33. Beikzadeh S, Akbarinejad A, Swift S, Perera J, Kilmartin PA, Travas-Sejdic J. Cellulose acetate electrospun nanofibers encapsulating Lemon Myrtle essential oil as active agent with potent and sustainable antimicrobial activity. Reactive Funct Polym. 2020;157:104769. https://doi.org/10.1016/j.reactfunctpolym.2020.104769.
  34. Weria Weisany, Shima Yousefi, Solmaz Pourbarghi Soufiani, Danial Pashang, David Julian McClements, Mehran Ghasemlou. Mesoporous silica nanoparticles: A versatile platform for encapsulation and delivery of essential oils for food applications, Adv Colloid Interface Sci. 2024;325. https://doi.org/10.1016/j.cis.2024.103116.