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By: Vivek L. Ahire, Vaibhavi D. Patil, Vaibhav G Badgujar, and Dinesh P. Badhane
(1-4)Student, Department of Pharmacognosy, Ahinsa Institute of Pharmacy, Dondaicha, Maharashtra, India
Nanocapsules, which are minute vesicles composed of a parent material shielded by a polymer casing to encase the drug in the nucleus while regulating the drug’s dispensation and targeting capacity, represent a ground-breaking advancement in the realm of pharmaceuticals. The purpose behind the creation of nanocapsules is to enhance their efficiency and functionality by leveraging various methodologies like polymerization, solvent diffusion, dialysis, and supercritical fluid technology. These nanocapsules introduce a groundbreaking strategy for drug delivery by furnishing a method for controlled release, enhancing the drug’s bioavailability, and facilitating precise delivery to specific anatomical locations in the body. Through rigorous exploration of different nanocapsule variations, their immense potential for effectively delivering a wide array of medications, particularly antibiotics, peptides, and proteins, has been unveiled, showcasing their exceptional adaptability and utility in medical treatment. By managing the pace of drug release, nanocapsules can significantly prolong the therapeutic impact of medications while diminishing undesirable side effects, thereby enhancing patient well-being. Moreover, nanocapsules perform a crucial function in amplifying the solvency and permeability of poorly soluble medications, which in turn fosters optimal absorption and dispersion within the body. Notably, in clinical scenarios, the demonstrated efficacy of nanocapsules in treating an extensive range of illnesses, encompassing malignancies, cardiovascular ailments, and infectious maladies, underscores their potential as a transformative technology in the realm of drug delivery. The promising versatility of nanocapsules in addressing a diverse spectrum of medical conditions signifies their importance as a multifaceted tool in the therapeutic landscap
Keywords : Nanocapsule, encapsulated, polymeric membrane, salting out, drug
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Refrences:
1. Ezhilarasi PN, Karthik P, Chhanwal N, Anandharamakrishnan C. Nanoencapsulation techniques for food bioactive components: A review. Food Bioprocess Technol. 2012;6(3):628–647. doi:10.1007/s11947-012-0944-0.
2. Nagavarma BVN, Yadav HKS, Ayaz A, Vasudha LS, Shivakumar H. Different techniques for preparation of polymeric nanoparticles– A review. Asian J Pharm Clin Res. 2012;5(Suppl 3):16–23.
3. Mironov V, Kasyanov V, Markwald RR. Nanotechnology in vascular tissue engineering: from nanoscaffolding towards rapid vessel biofabrication. Trends Biotechnol. 2008;26(6):338–44. doi:10.1016/j.tibtech.2008.03.001.
4. Guinebretière S, Briancon S, Lieto J, Mayer C, Fessi H. Study of the emulsion- diffusion of solvent: preparation and characterization of nanocapsules. Drug Dev Res 2002;57(1):18–33. doi:10.1002/ddr.10054.
5. Zaman H. Addressing solubility through nano based drug delivery systems. J Nanomed Nanotechnol. 2016;7(3):376. doi:10.4172/2157-7439.1000376.
6. El-Shabouri MH. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int J Pharm. 2002;249(1–2):101–108. doi:10.1016/S0378-5173(02)00461-1.
7. Nagarwal RC, Kant S, Singh PN, Maiti P, Pandit JK. Polymeric nanoparticulate system: A potential approach for ocular drug delivery. J Control Release. 2009;136(1):2–13. doi:10.1016/j.jconrel.2008.12.018.
8. Sindhwani S, Syed AM, Wilhelm S, Glancy DR, Chen YY, Dobosz M, Chan WC. Three-dimensional optical mapping of nanoparticle distribution in intact tissues. ACS Nano. 2016;10(5):5468–5478. doi:10.1021/acsnano.6b01879.
9. Kepley CL. Fullerenes in medicine; will it ever occur? J Nanomed Nanotechnol. 2012;3(6):1000e111. doi:10.4172/2157-7439.1000e111.
10. Mizuno K, Zhiyentayev T, Huang L, Khalil S, Nasim F, Tegos GP, Gali H, Jahnke A, Wharton T, Hamblin MR. Antimicrobial photodynamic therapy with functionalized fullerenes: Quantitative structure-activity relationships. J Nanomed Nanotechnol. 2011;2(2):1–9. doi:10.4172/2157-7439.1000109.
11. Modi S, Anderson BD. Determination of drug release kinetics from nanoparticles: overcoming pitfalls of the dynamic dialysis method. Mol Pharmaceutics. 2013;10(8):3076–3089. doi:10.1021/mp400154a.
12. Vauthier C, Bouchemal K. Methods for the preparation and manufacture of polymeric nanoparticles. Pharm Res. 2008;26(5):1025–1058. doi:10.1007/s11095-008-9800-3.
13. Boudad H, Legrand P, Lebas G, Cheron M, Duchene D, Ponchel G. Combined hydroxypropyl-β-cyclodextrin and poly (alkylcyanoacrylate) nanoparticles intended for oral administration of saquinavir. Int J Pharm. 2001;218(1–2):113–124. doi:10.1016/S0378-5173(01)00622-6.
14. Demir E. Genotoxicology of quantum dots used in medical and pharmaceutical sciences. Hereditary Genet. 2015;4(3):1000151. doi:10.4172/2161-1041.1000151.
15. Ingale AG, Chaudhari AN. Biogenic synthesis of nanoparticles and potential applications: An eco-friendly approach. J Nanomed Nanotechol. 2013;4(2):165. doi:10.4172/2157-7439.1000165.
16. Couvreur P, Barratt G, Fattal E, Legrand P, Vauthier C. Nanocapsule technology- A review. Crit Rev Ther Drug Carrier Syst. 2002;19(2):99–134.
17. Zha L, Hu W. Homogeneous crystal nucleation triggered by spinodal decomposition in polymer solutions. J Phys Chem B. 2007;111(39):11373–11378. doi:10.1021/jp068431c
