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133 articles for “Therapeutics”
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Gene Editing: Rewriting the Life and Consequences
Abstract: ABSTRACTGene editing is the rational, precise and candid modification of DNA sequences or genes in living cells and organisms, literally for anything and everything possible. Its manifestation ranging from designing disease resistant crops or therapeutic correction of defective genes responsible for myriad of debilitating diseases in human beings to reprogramming of organisms that can produce new sophisticated and potent biologicals. The possible implication of gene editing is wide ranging and …
Published in International Journal of Animal Biotechnology and Applications · Vol. 5, Issue 1-2, 2019 · pp. 10–19 Read article
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Screening And Docking Studies Of Phytocompounds For Targeting Breast Cancer Receptors And Proteins
Abstract: Phytocompounds, historically endorsed by Ayurveda, have long been recognized for their therapeutic potential in addressing various ailments, including complex diseases. Investigating their efficacy in breast cancer treatment has become a focus of research, employing molecular docking and ADME (Absorption, Distribution, Metabolism, and Excretion) analyses.A study was conducted utilizing 40 selected phytocompounds to assess their impact on various breast cancer receptors and proteins. Molecular docking simulations were performed using iGEMDock and …
Published in International Journal of Animal Biotechnology and Applications · Vol. 9, Issue 2, 2023 · pp. 9–19 Read article
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Comparative In Vitro Characterization of Curcumin Loaded Emulgel Formulations
Abstract: This study focused into the development of a curcumin-loaded emulgel. Different concentrations of Carbopol were used to formulate these emulgel. The in vitro evaluation of these formulations was carried out, focusing on parameters such as viscosity, rheology, pH, microbiological assay, and swelling index. The findings shed light on the promising potential of curcumin-loaded emulgels as a delivery system for herbal therapeutic carriers. The results contribute to the advancement of innovative …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 9, Issue 1, 2023 · pp. 43–51 Read article
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An In-depth Exploration: Unveiling the Computational Resources Utilized in Cancer Research
Abstract: It is a major challenge leading to mass morbidity and mortality in cancer, despite the efforts and clinical trials in the past. Cancer is a very crucial field of research that directly concerns human life that requires early identification, diagnosis, prognosis, and therapeutics. The resources and web servers play very important roles in cancer genomics and medical image analysis. Computational intelligence (is a set of computational methodologies involving design, application, …
Published in International Journal of Image Processing and Pattern Recognition · Vol. 9, Issue 2, 2023 · pp. 10–20 Read article
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Integrative Network Pharmacology and Molecular Docking Analysis Reveals Potent Inhibition of Ovarian Cancer-Associated Proteins by Curcuma Longa Derivatives
Abstract: Objectives: A network pharmacology approach and molecular docking study were employed to explore how the active ingredients of Curcuma longa interact with protein targets associated with ovarian cancer. The objective was to explore the mechanism of action of these active ingredients. Methods: In this study, a total of 14 derivatives of Curcuma longa were selected to evaluate their binding affinity with specific target proteins (HLA, CDK-41, EGFR, Tumor suppressor p53 …
Published in International Journal of Applied Nanotechnology · Vol. 9, Issue 1, 2023 · pp. 45–67 Read article
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A Review on Medical Perspective of Nanobiotechnology
Abstract: Nanobiotechnology is the utilization of nanotechnology in natural fields. Nanotechnology is a multidisciplinary field that right now selects methodology, innovation and office accessible in routine and propelled streets of building, material science, science and science. An exhaustive audit of the writing on the standards, constraints, difficulties, enhancements and uses of nanotechnology in therapeutic science was performed. Nanobiotechnology has large number of possibilities for propelling medicinal science in this manner enhancing …
Published in International journal of Nanobiotechnology · Vol. 1, Issue 1-2, 2015 · pp. 19–29 Read article
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Nanozymes: Unleashing the Catalytic Power of Nanomaterials in Biotechnology
Abstract: This article explores the fascinating field of nanozymes, which are nanomaterials that exhibit enzyme-like catalytic activities. Nanozymes have emerged as a powerful tool in biotechnology, offering advantages such as high stability, tunable activity, and easy synthesis. This article delves into the diverse applications of nanozymes, ranging from biosensing and bioimaging to environmental remediation and therapeutics. We will explore the underlying principles behind nanozyme catalysis, highlight key advancements, discuss challenges and …
Published in International journal of Nanobiotechnology · Vol. 9, Issue 1, 2023 · pp. 30–37 Read article
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Play Therapy: An Approach to Manage Childhood Problems
Abstract: “Birds Fly, fishes swim and children play” Landreth (1991:25) Childhood is the most pleasurable period of one’s lifetime. During this period children undergo various changes in areas such as physical, psychosocial, cognitive and moral development. Child learns to adapt to these changes in various ways. Adaptation from fantasy to real world imposes a lot of emotional ups and downs, which if left unattended, may turn in to emotional/ behavioural problems. …
Published in International Journal of Pediatric Nursing · Vol. 1, Issue 1, 2015 · pp. 22–28 Read article
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Women-Centric Healing Retreat Architecture: Translating Emotional, Social, Psychological, and Cultural Needs into Spatial Design
Abstract: This study investigates how the emotional, social, psychological, and cultural needs of women can inform the architectural design of healing retreat environments. Women often experience distinct pressures related to safety, emotional labour, social responsibilities, cultural expectations, and personal well-being, which can influence how they perceive and use spaces. Despite the growing interest in wellness architecture, many healing environments continue to follow gender-neutral approaches and may not adequately respond to women’s …
Published in International Journal of Landscape Planning and Architecture · Vol. 12, Issue 2, 2026 Read article
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Cryogenic Electron Microscopy Reveals Conformational Dynamics and Catalytic Mechanisms of Human Fatty Acid Synthase in De Novo Lipid Biosynthesis
Abstract: Fatty acid synthase (FASN) is a multifunctional homodimeric enzyme central to de novo fatty acid synthesis in mammals. Recent cryogenic electron microscopy (cryo-EM) studies have illuminated the structural basis of FASN catalysis, revealing multiple conformational states throughout the synthesis cycle. These findings show that the acyl carrier protein (ACP) domain dynamically shuttles substrates between spatially separated active sites, while the condensing and modifying regions remain structurally stable. In contrast to …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 8–25 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring compliance …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Modeling Twin-Twin Twin-to-Twin Transfusion SyndromeOutcomes: A Comprehensive Review
Abstract: Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies, characterized by unequal blood sharing between twins through placental vascular connections. This condition can lead to significant morbidity and mortality if not identified and managed promptly. This review explores the clinical outcomes associated with TTTS, emphasizing factors that influence prognosis and the effectiveness of current treatment modalities. A comprehensive analysis of recent therapeutic interventions, including fetoscopic laser ablation …
Published in International Journal of Obstetrics, Perinatal and Neonatal Nursing · Vol. 12, Issue 1, 2026 · pp. 26–32 Read article
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Animal Biotechnology: Finding a Balance Between New Ideas and Morality
Abstract: Animal biotechnology has become a revolutionary subject that combines genetics, farming, and medicine. It offers new ways to solve global problems like food security, disease management, and drug manufacturing. Scientists have used genetic engineering, cloning, transgenesis, and genome editing to make livestock more productive, generate animals that are immune to disease, and make useful scientific models. Transgenic animals are also being utilized more to make therapeutic proteins and help with …
Published in International Journal of Animal Biotechnology and Applications · Vol. 12, Issue 1, 2026 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: Abstract A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Advances in Applied Chemistry: From Electrochemical Biosensors and Gas Sensing to Sustainable Remediation and Nanofluid Engineering
Abstract: Applied chemistry acts as a crucial link between fundamental molecular science and practical technological innovation. It transforms theoretical knowledge into real-world applications that address challenges in healthcare, environment, and industry. This review highlights recent advancements in electrochemical biosensors, which offer rapid and sensitive diagnostic capabilities, along with modern gas detection technologies designed for improved safety and environmental monitoring. Significant attention is given to environmental remediation, particularly the use of activated …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 20–25 Read article
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Synthesis and Evaluation of Antifungal Properties of 2-((4-((6phenylimidazo[2,1-b][1,3,4]thiadiazole-2-yl)methoxy)phenoxy)methyl)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole Derived from Hydroquinone
Abstract: Thiadiazole, a heterocyclic core, has garnered significant interest from chemists seeking novel therapeutic agents. The synthetic route for the target compounds is depicted in Scheme 1. The compounds were synthesized with favorable yields through the condensation of hydroquinone with various organic reagents. They underwent physical characterization and were analyzed using spectroscopic methods, including infrared (FTIR) and NMR (1H, 13C) spectroscopy. The FT-IR spectrum of the product exhibited a ν(C=N) absorption …
Published in International Journal of Environmental Chemistry · Vol. 12, Issue 1, 2026 · pp. 76–82 Read article
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Pediatric Nursing Interventions for Addressing Childhood Anxiety, Behavioral Disorders, and Emotional Well-Being
Abstract: Childhood anxiety, behavioral disorders, and emotional disturbances represent a growing global public health concern, significantly affecting children’s developmental trajectories, academic performance, and social functioning. These conditions, including anxiety disorders, attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and mood-related disturbances, require early identification and multidisciplinary management. Pediatric nurses play a pivotal role in addressing these challenges through assessment, therapeutic interventions, family education, and psychosocial support. Their involvement spans across preventive, curative, …
Published in International Journal of Pediatric Nursing · Vol. 12, Issue 2, 2026 · pp. 23–34 Read article
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Applications of Bionanocomposites in Healing & Treatment of Tendon & Ligament Injuries.
Abstract: Tendon and tissue injuries are difficult to manage because of their poor natural healing ability and the risk of scar tissue and reinjury. Nanotechnology has created materials that can closely mimic natural biological structures, opening up new possibilities for regenerative medicine in recent years. In the creation of scaffolds and delivery systems for tissue repair, nanomaterials are very useful. The extracellular matrix's nanoscale configuration is replicated using electrospun nanofiber scaffolds, …
Published in International Journal of Composite and Constituent Materials · Vol. 12, Issue 1, 2026 · pp. 17–41 Read article
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An Overview on Nanomaterial-Enabled Electronic Skin for Physiological Sensing and Biomedical Use
Abstract: Imagining a world in which prosthetics have the ability to feel, robots are able to detect even the faintest touch, and wearable health monitors are able to track your well-being in a seamless manner. Electronic skin, often known as e-skin, is a revolutionary technology that is set to alter the way in which we interact with the world. This vision has become a reality thanks to their development. What is …
Published in International journal of Nanobiotechnology · Vol. 12, Issue 1, 2026 · pp. 53–62 Read article
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Xerostomia and Salivary Gland Hypofunction: From Pathophysiology to Nanotechnology‑Enabled Regenerative Therapies
Abstract: Xerostomia, the subjective sensation of oral dryness, is a common yet frequently underrecognized condition with multifactorial etiology and substantial consequences for oral and systemic health. Salivary gland hypofunction underlies many, but not all, cases and may result from medication use, head and neck radiotherapy, autoimmune disease, systemic illnesses, or age-related and hormonal changes. Persistent xerostomia impairs mastication, swallowing, speech, taste, and sleep, and predisposes to dental caries, periodontal disease, oral …
Published in International journal of Nanobiotechnology · Vol. 12, Issue 1, 2026 · pp. 1–27 Read article