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11 articles for “Mass spectrometry”
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Software Contributions to Analytical Instruments
Abstract: Laboratory instruments used in the analysis of the sample or preparation of raw materials are crucial in research and business. Such features as accurately measured values and data coverage. The coordination between software and these instruments has changed their roles, gaining flexibility, accuracy and efficiency of work. This paper aims to outline the various roles of software in the analytical process. Instruments, describing the progress in data obtaining, analysis, and …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 1–15 Read article
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Recent Advances in Analytical and Applied Chemistry: A Comprehensive Review
Abstract: Analytical and Applied Chemistry form the backbone of modern scientific progress, connecting fundamental molecular insights with real-world industrial and societal applications. Over the past decade, these fields have undergone significant transformation, driven by the need for sustainability, precision, and efficiency. This review highlights key advancements in green analytical chemistry (GAC), high-resolution mass spectrometry (HRMS), and the incorporation of nanotechnology into chemical sensing, while also examining their broader implications in applied …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 36–41 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring compliance …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Synthesis, Structural Elucidation, and Antimicrobial Screening of a Cobalt (II) Coordination Compound Derived from a Thiophene-Containing Schiff Base
Abstract: Abstract An N, O-chelating azomethine Schiff base ligand (HL), chemically identified as 2-{[(thiophen-2-yl) methylidene] amino} benzoic acid, was synthesized by an equimolar condensation reaction between thiophene-2-carbaldehyde and anthranilic acid in absolute ethanol in the presence of a catalytic amount of acetic acid. The corresponding cobalt (II) complex, formulated as [Co(L)₂] · 2H₂O, was prepared by refluxing two equivalents of the ligand with one equivalent of cobalt (II) acetate tetrahydrate in …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 2, 2026 · pp. 1–7 Read article
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Establishment of a Sensitive LC-MS Method for Pharmacokinetic Evaluation of Decitabine and Cedazuridie in Rat Plasma
Abstract: Abstract A simple, rapid, and highly sensitive liquid chromatography–mass spectrometry (LC–MS) method was successfully developed and validated for the simultaneous determination of Decitabine and Cedazuridine in plasma matrices. The method demonstrated excellent linearity across the selected calibration range, with correlation coefficients (R²) consistently exceeding 0.999 for both analytes, indicating strong analytical performance. Method validation was carried out in accordance with ICH Q2(R2) and US FDA bioanalytical method validation guidelines, ensuring …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 34–42 Read article
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Green and Nanotechnology Approaches for the Determination of Tungsten (VI): A Modern Analytical Perspective
Abstract: The determination of tungsten (VI) has gained increasing importance due to its extensive industrial applications and growing environmental relevance. Tungsten is widely used in alloys, catalysts, electronics, and energy systems, leading to its release into environmental matrices such as water, soil, and biological systems. Accurate monitoring of tungsten at trace and ultra-trace levels is therefore essential for environmental assessment and industrial quality control. Conventional analytical techniques, including inductively coupled plasma …
Published in International Journal of Analytical and Applied Chemistry · Vol. 12, Issue 1, 2026 · pp. 26–35 Read article
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Reactivity of Niobium(V) ComplexTowards Hydroxamate Ligands
Abstract: A niobium(V) complex with the composition [NbCl(OC₆H₄CH(CH₃)₂-2)₄] was synthesized by reacting niobium pentachloride with four equivalents of 2-isopropylphenol in carbon tetrachloride as a solvent, yielding the product in good quantity. The complex was characterized using elemental analysis, molar conductance measurements, IR spectroscopy, ¹H and ¹³C NMR spectroscopy, and mass spectrometry. Spectroscopic results indicate that the complex exists in a dimeric form, with bridging occurring through isopropylphenoxo ligands. X-ray diffraction analysis …
Published in International Journal of Energetic Materials · Vol. 12, Issue 1, 2026 · pp. 1–6 Read article
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How Heavy Metal Minerals Affect the Quality of Soil and Groundwater
Abstract: Heavy metal minerals polluting soil and groundwater is becoming a major environmental issue because these components are not biodegradable and last a long time. This study examines the degree to which heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), and chromium (Cr), affect the chemical and physical characteristics of soil and groundwater in regions impacted by industrial, agricultural, and mining operations. Soil and water samples were obtained …
Published in International Journal of Environmental Chemistry · Vol. 11, Issue 2, 2025 · pp. 9–20 Read article
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Major Analytical Problems in Current Pharmaceutical Drug Products
Abstract: Substances of pharmaceutical drug products go through thorough analyses to check the safety, efficacy as well as the quality of the final product. There are a number of shortcomings even though much has been done in the analytical methods used in recalls. Such challenges are those concerning method validation, sensitivity, specificity, reproducibility, and regulation. This article on major analytical problems in current pharmaceutical drug products outlines major limitations in the …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 1, 2025 · pp. 29–39 Read article
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Isolation and Characterization of Alkaloidsfrom Ancistrocladus Heyneanus Leaves: A Phytochemical Study
Abstract: Leaves of Ancistrocladus heyneanus were collected from the forest of the Matheran hills of Maharashtra. From these leaves, alkaloids were extracted using dichloromethane, and two new monomeric Naphthyl-iso-quinoline alkaloids, Youndamine A and Ancistrocline were isolated using TLC and HPLC. HPLC/MS and NMR further identified the patient. The present study involves the collection and chemical investigation of the leaves of Ancistrocladus heyneanus, a plant species found in the forested regions of …
Published in International Journal of Analytical and Applied Chemistry · Vol. 10, Issue 2, 2024 · pp. 7–20 Read article
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Heterocyclic Oxadiazole Derivatives Through Various Spectroscopic Techniques as UV, IR.
Abstract: The study focuses on the synthesis, characterization, and analysis of heterocyclic oxadiazole derivatives using various spectroscopic techniques, including UV-visible (UV-Vis) spectroscopy and infrared (IR) spectroscopy. Oxadiazoles are a type of five-membered heterocyclic compounds with nitrogen and oxygen atoms. They are important in medical chemistry and materials research and show a wide range of biological activity. The synthesized oxadiazole derivatives were characterized through UV-Vis spectroscopy to investigate their electronic transitions and …
Published in International Journal of Analytical and Applied Chemistry · Vol. 10, Issue 1, 2024 · pp. 1–8 Read article