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133 articles for “Therapeutics”
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Advancement of Poly-(ADP – Ribose) Polymerase (PARP) Inhibitors in Cancer Progression and Treatment
Abstract: DNA repair mechanisms are the most common and potential targets in cancer treatment. PARP enzymes play a crucial role in detection of DNA damage and its repair and also in apoptosis. Detailed knowledge of these mechanisms leads to the development of poly-(ADP-Ribose) polymerase (PARP) inhibitors as vigorous anticancer drugs with specific action. PARP inhibitors can selectivity kill tumours with deficiencies in DNA repair proteins like BRCA1/2, exploiting synthetic lethality concept. …
Published in International Journal of Animal Biotechnology and Applications · Vol. 1, Issue 1, 2015 Read article
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Anti-anxiety Evaluation of Hydroalcoholic Root Extract of Lagerstroemia speciosa in Swiss Albino Rats
Abstract: After going through numerous pharmaceutical databases for reviewing the present status regarding the exploration of anti-anxiety potentials of root hydroalcoholic extract of Lagerstroemia speciosa (Family: Lythraceae), no such reports have been found so far. Therefore, the necessity of anti-anxiety exploration was taken into account for investigating the above through the EPM model. The L. speciosa root hydroalcoholic extract demonstrated an excellent reduction of anxiety in the experimental animals. This exploration …
Published in International Journal of Animal Biotechnology and Applications · Vol. 6, Issue 1, 2020 · pp. 6–9 Read article
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Virosomes: Understanding the Modern Concepts and Latest Applications
Abstract: A virosome is a cutting-edge hybrid drug delivery method that combines the benefits of viral and non-viral vectors. A virosome has been shown to transport a variety of physiologically active substances, including nucleic acids, peptides, proteins, and tiny chemical compounds, according to research. Surface changes of virosomes may be used to enable targeted medication delivery utilising virosome-based devices. There are presently a variety of virosome-based preventive and therapeutic medicines on …
Published in International Journal of Animal Biotechnology and Applications · Vol. 7, Issue 1, 2021 · pp. 20–31 Read article
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Using of Rat Model Over Other Species: A Review
Abstract: The first domesticated morphological features to be used in studies were rats. Scientists employed the brown rat Rattus norvegicus to study human biology and therapeutics two decades ago, focusing on the consequences of hunger and oxygen deprivation. Rats have been used to answer a wide range of basic science problems relevant to common human ailments in the fields of pharmacology, immunology, physiology, nutrition, behaviour, learning, and toxicity. The article gives …
Published in International Journal of Animal Biotechnology and Applications · Vol. 8, Issue 1, 2022 · pp. 17–20 Read article
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Possible drugs for Huntington’s disease from Capsicum annuum developed using molecular docking against Huntington protein
Abstract: Objective: To evaluate the efficacy of Capsicum annuum as a suitable plant for the treatment of Huntington’s disease using Pyrx. Huntington’s disease results in the damage of the nervous system over a period of time. For this study, we take into consideration Capsaicin, a compound obtained from the fruit of Capsicum annuum (bell pepper) responsible for giving the fruit it’s pungent odor. Studies show that Capsaicin plays a crucial role …
Published in International Journal of Animal Biotechnology and Applications · Vol. 9, Issue 2, 2023 · pp. 27–29 Read article
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Drug Delivery Systems
Abstract: Drug delivery is the strategy or procedure of overseeing a pharmaceutical compound to accomplish a restorative impact in human or animals. For the treatment of human illnesses, nasal and pneumonic routes of drug delivery are increasing expanding significance. These routes give promising contrasting options to parenteral drug delivery especially for peptide and protein therapeutics. For this reason, a few drug delivery frameworks have been figured and are being explored for …
Published in International Journal of Industrial Biotechnology and Biomaterials · Vol. 2, Issue 2, 2016 · pp. 6–10 Read article
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Agronomy of Rice Husks
Abstract: Rice husk and hull is the waste material of rice mill. These have been hard, fibrous and abraded capabilities. Bio active and biodegradable rice husk/hull have been studied to claim remaining form by firing at scaled opts of amorphous and crystal forms of silica. Metallic constitutive like iron, manganese, sodium, potassium, lead, copper have suggestive towards route to subscribe purest form after firing. Preparations out of raw forms have subjectively …
Published in International Journal of Agrochemistry · Vol. 6, Issue 1, 2020 · pp. 52–57 Read article
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Chemical Compositions of Three Economic Tuber Crops Grown In South East, Nigeria
Abstract: Yam (Dioscorea spp) are known for their climbing properties, twining stems which coils readily around a stake and exhibiting glaborous leaves. Via root system, they are perennial but are usually grown as annual crops. Yam is economically important because it serves a staple food for millions of people in Africa, as well as Nigeria. There is limited information on nutrients composition of Nigerian foods. As a result, nutrients intake from …
Published in International Journal of Agrochemistry · Vol. 7, Issue 2, 2021 · pp. 22–26 Read article
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Indian Green Flora-“Ramban” to Asthma
Abstract: Some Population India and in world is affected by Bronchoconstriction and asthma. There is one of the severe disorder to which emergency medicine should be availablE. There are allopathic, Ayurvedic, siddha, Unani and Homeopathic medicine are available certain restriction are made with the use of such bronchodilator. If the population of such disease is not cure by proper medicament then it may cause unhealthy and disturbed economic condition to individual, …
Published in International Journal of Green Chemistry · Vol. 9, Issue 2, 2023 · pp. 15–25 Read article
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Factors Attributed to Antimicrobial Activity of Honey and Its Analysis on Some Selected Microorganisms
Abstract: To summaries, we believe that honey is an intriguing and promising alternative to traditional antibiotics and that it should be taken more seriously as a therapeutic agent. Honey is widely regarded as the world's oldest medicine, and for good reason. Since time immemorial, it is believed to heal wounds along with antibiotic. The immunomodulatory present in it is also known to give proper wound healing. The antibiotic in many honeys …
Published in International Journal of Analytical and Applied Chemistry · Vol. 7, Issue 2, 2021 · pp. 37–43 Read article
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Ayurveda as an alternative Medicine for SARS-CoV
Abstract: The goal of this study was to look at the clinical evidence for complementary and alternative medicine treatments for major depressive disorder. The phrase depressive disorder was combined with St John’s wort, S-adenosylmethionine (SAM-e), exercise, acupuncture, omega-3 fatty acids, and folate in a PubMed search from January 1966 to February 2010. Only relevant human trials were selected. COVID-19, the current global health emergency, is not the first-time coronaviruses have posed …
Published in International Journal of Analytical and Applied Chemistry · Vol. 7, Issue 2, 2021 · pp. 28–36 Read article
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Investigations of Diabetic Retinopathy Algorithms in Retinal Fundus Images
Abstract: Diabetic Retinopathy (DR) location is a point of high enthusiasm for therapeutic picture investigation since the examination of DR is essential for finding, treatment arranging and execution, and assessment of clinical results in ophthalmology. Programmed or self-loader DR location can bolster clinicians in playing out these undertakings. Diverse restorative imaging methods are at present utilized in clinical practice and a suitable decision of the identification calculation is required to manage …
Published in International Journal of Image Processing and Pattern Recognition · Vol. 6, Issue 1, 2020 · pp. 14–26 Read article
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Synthesis of Zinc Oxide Nanoparticles by Simple Hydrothermal Process
Abstract: Rapid synthesis of zinc oxide nanoparticles through economically feasible hydrothermal approach is highly desirable. In this study, we have developed a method to synthesize zinc oxide nanoparticles by using simple hydrothermal process in aqueous zinc salt solution (ZnCl2) without need of any surfactant or external energy. This experimentation produced physiologically stable, bio-compatible ZnONPs which may be used for targeted drug delivery that offers enhanced therapeutic efficacy and minimal side effects. …
Published in International Journal of Applied Nanotechnology · Vol. 2, Issue 1, 2016 · pp. 8–16 Read article
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Potential of Novel Carriers for Effective Management of Acetaminophen Induced Hepatotoxicity
Abstract: Liver is a vital organ of the human body. It plays an important role in the human body. Acetaminophen when taken in therapeutic doses, it is used in the treatment of various conditions. Hepatotoxicity is the prime factor responsible for drug withdrawal from the market. There is no doubt that hepatotoxicity requires considerable attention and that every viable measure be taken towards an efficient mechanism for hepatoprotection. The overdose of …
Published in International Journal of Applied Nanotechnology · Vol. 1, Issue 1-2, 2015 Read article
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Melanoma’s Nemesis: Assessing the Pharmacological Impact of Curcumin and its Analogues as Inhibitors of Identified Biomarkers Via Network Pharmacology
Abstract: Objectives: Since the advent of next-generation sequencing, melanoma has been recognized as an immensely heterogeneous disease, leading to the discovery of numerous underlying genetic drivers over time. Bioinformatic and machine learning analyses have become increasingly prevalent in risk stratifying melanoma patients with high accuracy, leveraging genetic, clinical, and histopathological inputs. Via various research curcumin has been identified and also shown therapeutic efficacy in Melanoma. In order to reveal the interactions …
Published in International Journal of Applied Nanotechnology · Vol. 9, Issue 1, 2023 · pp. 33–44 Read article
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Exploring Aptamer Applications in Analytical Chemistry, Medicine, and Food Industry.
Abstract: Many studies have been conducted and a large number of isolated aptamers for different targets have been used since Ellington and Gold's independent description of aptamer and its in vitro selection method, known as SELEX, in 1990. With excellent binding affinity and selectivity, aptamers can bind to a variety of targets, such as haptens, small organic molecules, inorganic compounds, and even entire cells. Currently, aptamers for a large variety of …
Published in International Journal of Energetic Materials · Vol. 9, Issue 1, 2023 · pp. 21–27 Read article
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Colloidal Gold Nanoparticles for Biomedical Applications
Abstract: The main problem of drug-based therapy is that the introduced compound is not located in the target area and it is widely dispersed. Colloidal nanoparticle-based treatment can benefit the situation. The human body can concentrate inert nanoparticle by passive targeting. The therapeutic delivery system can be promoted using the surface of gold nanoparticle so that it only targets the specific issues by active targeting. In passive targeting colloidal GNPs can …
Published in International journal of Nanobiotechnology · Vol. 4, Issue 1, 2018 · pp. 16–18 Read article
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Nanotechnology Based Drug Delivery System for Cancer Therapy
Abstract: Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and material science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Several therapeutic nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. This review examines some of the approved formulations …
Published in International journal of Nanobiotechnology · Vol. 5, Issue 2, 2019 · pp. 8–36 Read article
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Indian Perspective of COVID-19 Pandemic
Abstract: Year 2020 started with a deadly viral disease COVID-19 induced by novel corona virus. This happened not for the first time because SARS and MARS had been other corona viral diseases developed in the past. As per sources the disease originated from Wuhan China, spread to almost all the countries and thus declared as pandemic. Evidence based medical therapy still has not been available. Prevention is only known effective measure. …
Published in International journal of Nanobiotechnology · Vol. 7, Issue 1, 2021 · pp. 18–23 Read article
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Magnetic field guided diluted magnetic semiconductor ZnxFe2-xO3 Nanostructures for applications in biomedical and biosensors
Abstract: The magnetic field guided nanoparticles are studied in the viewpoint of diluted magnetic semiconductor. Different structures and properties of Zn doped α-Fe 2 O 3 nanostructure is presented in theoretical point of view. In these regard, Weiss molecular filed theory, DFTB model, and DLVO theory are used to describe particle agglomeration, aggregation, electrostatic interactions, and magnetic interactions between Zn doped iron oxide nanocolloids. In addition, the nature of interactions between …
Published in International journal of Nanobiotechnology · Vol. 9, Issue 2, 2023 · pp. 18–30 Read article