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24 articles for “heterocyclic synthesis”
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Aromaticity-Guided Synthesis and Reactivity of Heterocyclic Compounds: Structural Insights and Applications
Abstract: The concept of aromaticity serves as a fundamental framework for understanding the structural and electronic characteristics of heterocyclic compounds, which play a crucial role in modern synthetic chemistry. Aromatic compounds, characterized by cyclic planar systems with delocalized π-electrons, follow the Hückel rule, conferring significant stability to heterocyclic structures. The incorporation of heteroatoms, such as nitrogen, oxygen, and sulphur, within these rings profoundly influences electron distribution, molecular reactivity, and synthetic pathways. …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 11, Issue 2, 2026 · pp. 1–7 Read article
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One-Pot Multicomponent Reactions: A Versatile Approach for Heterocyclic Compound Synthesis
Abstract: Multicomponent reactions (MCRs) represent an efficient and versatile approach in organic synthesis, enabling the formation of complex molecules through a single, one-pot procedure. This methodology is particularly advantageous for the synthesis of heterocyclic compounds that are prevalent in numerous biologically active molecules and pharmaceuticals. The one-pot nature of MCRs allows for the simultaneous combination of three or more reactants, leading to high atom economy, reduced reaction times, and minimized purification …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 10, Issue 1, 2025 · pp. 1–7 Read article
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Review Paper on Mannich Bases for Heterocyclic Compound Synthesis
Abstract: Mannich bases are the Lewis bases which are β-amino carbonyl compounds synthesized as the endproducts of well known condensation reaction known as Mannich reaction. These are theaminoalkylation reactions involving the formation of carbon-carbon, carbon-Nitrogen, carbonsulphurbonds. Mannich bases of 2-furylmethylketone, catechol, 4-chlorophenol, derivative ofberberine, lawsone, anisaldehyde, benzaldehyde show diversity of biological activities. Mannichreaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesisof a widespread variety …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 7, Issue 1, 2021 · pp. 39–50 Read article
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Advance in the Synthesis of Oxadiazole Based Heterocyclic Compound
Abstract: The five members of the heterocyclic ring 1,3,4-oxadiazole are necessary for the production of strong bioactive molecules. Numerous pharmacological effects, including anti-inflammatory, antibacterial, anticancer, antitubercular, anticonvulsant, anti-HIV, hypoglycemic, and antioxidant qualities, are exhibited by this intriguing class of chemicals. We have created four novel 1,3,4-oxadiazole compounds in the continuing study, which are sourced from the NSAID Ibuprofen. Melting point analysis and TLC were used to verify the compounds' purity. Open …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 9, Issue 2, 2023 · pp. 10–15 Read article
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Synthesis of Different types of Heterocycles are used by Claisen rearrangement reaction
Abstract: The Claisen rearrangement is a powerful tool for carbon-carbon bond-forming reaction which was discovered by Rainer Ludwig Claisen. The discovery of the Claisen rearrangement nearly a century ago accessible a potentially useful synthetic tool to the organic chemist. Utility of this rearrangement over the decades has been realized and the reaction has drawn the consideration of numerous research groups, which has been showed in the number of publication on the …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 6, Issue 1, 2020 · pp. 44–48 Read article
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Synthesis and Production of Innovative Energetic Materials
Abstract: Energetic materials such as explosives, propellants and pyrotechnics are used world widely for civilian and military applications. There are research programs worldwide to develop pyrotechnics with reduced smoke and new explosives and propellants with higher performance or improved insensitivity to thermal or shock insults. In current years, the synthesis of energetic and heterocyclic compounds have received a great amount of interest. Heterocycles generally have a higher heat of formation, density, …
Published in International Journal of Energetic Materials · Vol. 3, Issue 1, 2017 · pp. 5–10 Read article
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Synthesis and Evaluation of Antimicrobial Activity of Some Heterocyclic Moieties of Pyrazole Derivatives
Abstract: In a successful trial to synthesize pyrazole derivatives, acetophenone was, first, reacted with phenylhydrazine producing the Schiffs’s base condensation product (E)-1-phenyl-2-(2-phenylethylidene) hydrazine 1. The application of Vilsmeier Haack’s reaction on this product afforded the cyclization product (1,3-diphenyl-1H-pyrazole-4-carbaldehyde 2 as a pyrazole derivative in good yield percentage. The treatment of (1,3-diphenyl-1H-pyrazole-4-carbaldehyde (2) with acetophenone results in the formation of another pyrazole derivative (3), having a chalcone moiety.The chemical structure of newly …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 10, Issue 1, 2025 · pp. 26–36 Read article
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Mechanistic Insights into Solvent-Controlled Stepwise and Concerted Cycloadditions of the Propadienyl Cation with Oxoamides: A DFT Study
Abstract: AbstractOxazoles constitute an important class of heterocycles with widespread applications in medicinal chemistry and materials science, yet the mechanistic features governing their formation via cationic cycloaddition reactions remain incompletely understood. In this work, we present a comprehensive density functional theory (DFT) investigation into the reaction between the propadienyl cation and oxoamides as a model system for oxazole ring formation. Using the CAM-B3LYP/6–31+G(d,p) level of theory, we systematically compare gas-phase reactivity …
Published in International journal of Thermodynamics and Chemical Kinetics · Vol. 12, Issue 1, 2026 · pp. 8–17 Read article
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Synthetic Studies on Fused Benzodiazepines: A Class of Medicinally Privileged Heterocycles
Abstract: 1,4-Benzodiazepine is an important nitrogen heterocyclic scaffold because of its presence in various natural products, drugs and biologically active molecules. Henceforth, it is also known as privileged heterocycle in the field of medicinal to synthetic organic chemistry. Reactions towards the synthesis of five- and six- membered heterocycles are very easy and facile. On the other hand, synthesis of medium ring heterocycles is more difficult because of the thermodynamic limitations. Thus …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 4, Issue 2, 2018 · pp. 44–59 Read article
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Study of the Effect of SLS Loading on the One-Pot Synthesis of Substituted Piperidines
Abstract: Piperidine derivatives represent a vital class of nitrogen-containing heterocycles with extensive pharmacological and industrial significance. Their synthesis has garnered considerable interest due to their presence in numerous bioactive molecules, including drugs with CNS activity, analgesic properties, and antimicrobial effects. Traditional multi-step synthetic pathways are often time-consuming and resource-intensive. To address this, one-pot multicomponent reactions (MCRs) have emerged as an efficient and eco-friendly alternative, allowing for the rapid construction of complex …
Published in International Journal of Green Chemistry · Vol. 12, Issue 1, 2026 · pp. 1–9 Read article
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Exploring Thermodynamic Heterocyclic Compounds: A Comprehensive Analysis
Abstract: Heterocyclic compounds constitute a significant class of organic molecules with diverse applications in various fields including pharmaceuticals, materials science, and agrochemicals. Understanding their thermodynamic properties is crucial for elucidating their behavior in different environments and optimizing their applications. This comprehensive analysis delves into the thermodynamic aspects of heterocyclic compounds, encompassing their synthesis, structural characteristics, and energetics. The review begins by outlining the fundamental principles governing the thermodynamics of heterocyclic compounds, …
Published in International journal of Thermodynamics and Chemical Kinetics · Vol. 9, Issue 1, 2023 · pp. 40–46 Read article
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SYNTHESIS OF NICOTINE CORE UNIT OF 2-NITRO-3-PHENYLPROPAN-1-OL FROM BAYLIS-HILLMAN ADDUCTS DERIVED FROM NITRO OLEFINS.
Abstract: The Baylis-Hillman adducts derived from nitroolefins have been conveniently transformed into 2- nitro-3-phenylpropan-1-ol via simple reaction condition. These compounds have been demonstrated for the synthesis of reduction olefin is highly biological reactive compounds. This novel nitro derivative of the BH adduct was simply treated with mole percentage of iron and acetic acid in reactive condition. Hence this novel nicotine core unit compounds were very intrusting and new opportunities for the …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 7, Issue 2, 2021 · pp. 26–30 Read article
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Heterocyclic Oxadiazole Derivatives Through Various Spectroscopic Techniques as UV, IR.
Abstract: The study focuses on the synthesis, characterization, and analysis of heterocyclic oxadiazole derivatives using various spectroscopic techniques, including UV-visible (UV-Vis) spectroscopy and infrared (IR) spectroscopy. Oxadiazoles are a type of five-membered heterocyclic compounds with nitrogen and oxygen atoms. They are important in medical chemistry and materials research and show a wide range of biological activity. The synthesized oxadiazole derivatives were characterized through UV-Vis spectroscopy to investigate their electronic transitions and …
Published in International Journal of Analytical and Applied Chemistry · Vol. 10, Issue 1, 2024 · pp. 1–8 Read article
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Recent Advances in Fused Heterocyclic Pyridine Compounds for Bioactive Anti-Inflammatory Drug Discovery
Abstract: Heterocyclic compounds, particularly those fused with pyridine rings, have emerged as promising candidates in the search for novel bioactive agents with anti-inflammatory properties. This review highlights recent advances in the discovery and development of fused heterocyclic pyridine compounds as potential anti-inflammatory drugs. The unique structural properties of fused heterocycles contribute to their ability to modulate key inflammatory pathways. By targeting specific molecular targets involved in inflammation, such as cytokines, enzymes, …
Published in International Journal of Chemical Separation Technology · Vol. 10, Issue 1, 2024 · pp. 1–7 Read article
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Grindstone Chemistry: Facile Green Chemical Approach for the Synthesis of Pyran Scaffolds
Abstract: Chemical transformations through physical grinding of precursors using mortar and pestle are usually termed as ‘Grindstone Chemistry’. The main feature of this method such as does not require costly equipment, allows solvent and waste-free transformations under mild conditions, and normally involves short reaction time, high product yield and selectivity made this protocol attractive among unconventional synthetic approaches. On the other hand, Pyrans are important heterocyclic structures found applications in various …
Published in International Journal of Green Chemistry · Vol. 6, Issue 2, 2020 · pp. 30–40 Read article
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Different type of catalysts used in the Baylis-Hillman reaction
Abstract: The Baylis-Hillman reaction in the present-day version is an atom-economic carbon-carbon bond-forming reaction between the α-position of the activated alkenes and carbon electrophiles under the influence of a catalyst or catalytic system offering diverse classes of densely functionalized molecules. If the substrate contains both the activated alkene and electrophile components in appropriate positions, there is the possibility of developing an intramolecular version of this reaction leading to the synthesis of …
Published in International Journal of Chemical Synthesis and Chemical Reactions · Vol. 5, Issue 2, 2019 · pp. 30–37 Read article
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Synthesis and Antifungal Activity of Some Bis-1,4-(3-Mercapto-5-Oxymethyl-1,2,4-Triazole-5-yl) Benzene & Bis-1,4-(5-Amino-2-Oxymethyl-1,3,4-Thiadiazole-2-yl) Benzene
Abstract: Heterocyclic compounds are well known for their pharmacological application. Among all N-containing heterocyclic compounds, triazole emerges superior application. Triazole have two core structures 1,2,4-triazole and 1,2,3-triazoles. They both can give a broad range of substitutions with their structures, due to these characteristics, they have significant biological applications. They are also important in organocatalysis, agrochemicals, and material science. We aim to explore suitable molecular modifications in thiadiazole and triazole derivatives to …
Published in International Journal of Agrochemistry · Vol. 11, Issue 2, 2025 · pp. 9–15 Read article
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Synthesis and Evaluation of Antifungal Properties of 2-((4-((6phenylimidazo[2,1-b][1,3,4]thiadiazole-2-yl)methoxy)phenoxy)methyl)-6-phenylimidazo[2,1-b][1,3,4] thiadiazole Derived from Hydroquinone
Abstract: Thiadiazole, a heterocyclic core, has garnered significant interest from chemists seeking novel therapeutic agents. The synthetic route for the target compounds is depicted in Scheme 1. The compounds were synthesized with favorable yields through the condensation of hydroquinone with various organic reagents. They underwent physical characterization and were analyzed using spectroscopic methods, including infrared (FTIR) and NMR (1H, 13C) spectroscopy. The FT-IR spectrum of the product exhibited a ν(C=N) absorption …
Published in International Journal of Environmental Chemistry · Vol. 12, Issue 1, 2026 · pp. 76–82 Read article
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Synthesis, computational analysis and biological evaluation of novel thiazolidinone derivatives
Abstract: Through multicomponent methods including 2-chloroquinoline-3-carbaldehyde,(1- methylpiperidin-4-yl) methanamine and thioglycolic acid, the work focuses on creating and assessing the antibacterial characteristics of a new 4-thiazolidinone heterocyclic. Spectral testing was used to validate the molecules' structures. All the compounds were screened for their antibacterial and antifungal activity using Agar-well diffusion; compared to the reference drugs such as Ampicillin, Ciprofloxacin, and Griseofulvin, the examined compounds demonstrated moderate to good efficacy, with inhibition zone …
Published in International Journal of Analytical and Applied Chemistry · Vol. 11, Issue 2, 2025 · pp. 30–40 Read article
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Review on the Synthesis, Reactions, Biological Importance and Application of Phthalic Anhydride
Abstract: Phthalic anhydride (also known as IUPAC name: benzofurandione), abbreviated PA, represents a cyclic organic substance derived through the oxidative transformation of xylene or naphthalene compounds. The coexistence of the benzene and furan-1, 3-dione ring structures significantly contributes to the formation of numerous heterocycles and certain polycyclic molecules. In organic chemistry, the aromatic system within para-amino benzoic acid acts as a reactive site towards double bond-containing molecules like those featuring an …
Published in International Journal of Energetic Materials · Vol. 11, Issue 2, 2025 · pp. 12–20 Read article